Neurotoxicity Associated With Dimethyl Sulfoxide Used in Allogeneic Stem Cell Transplantation.
J Pediatr Hematol Oncol
; 39(5): e297-e299, 2017 07.
Article
em En
| MEDLINE
| ID: mdl-28121745
ABSTRACT
Dimethyl sulfoxide (DMSO) is a cryoprotective agent used in storage of frozen stem cells in stem cell transplantation. Central nervous system side effects of DMSO such as epileptic seizures, stroke, transient global amnesia, and temporary leucoencephalopathy are rarely seen. Here, we report a pediatric patient who developed seizures after DMSO-cryopreserved stem cell infusion and whose magnetic resonance imaging of the brain demonstrated parietal and occipital focal cortical T2-signal intensity increase. DMSO toxicity should be kept in mind in patients who received cryopreserved stem cell infusion and magnetic resonance imaging may be helpful in differential diagnosis of central nervous system involvement.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Dimetil Sulfóxido
/
Síndromes Neurotóxicas
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Crioprotetores
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Transplante de Células-Tronco
Tipo de estudo:
Diagnostic_studies
/
Risk_factors_studies
Limite:
Adolescent
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Female
/
Humans
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article