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A Physiologically-Based Pharmacokinetic Modeling Approach To Predict Drug-Drug Interactions of Sonidegib (LDE225) with Perpetrators of CYP3A in Cancer Patients.
Einolf, Heidi J; Zhou, Jocelyn; Won, Christina; Wang, Lai; Rebello, Sam.
Afiliação
  • Einolf HJ; Department of Drug Metabolism and Pharmacokinetics (H.J.E., L.W., S.R.) and Oncology Clinical Pharmacology (J.Z., C.W.), Novartis, East Hanover, New Jersey 07936 heidi.einolf@novartis.com.
  • Zhou J; Department of Drug Metabolism and Pharmacokinetics (H.J.E., L.W., S.R.) and Oncology Clinical Pharmacology (J.Z., C.W.), Novartis, East Hanover, New Jersey 07936.
  • Won C; Department of Drug Metabolism and Pharmacokinetics (H.J.E., L.W., S.R.) and Oncology Clinical Pharmacology (J.Z., C.W.), Novartis, East Hanover, New Jersey 07936.
  • Wang L; Department of Drug Metabolism and Pharmacokinetics (H.J.E., L.W., S.R.) and Oncology Clinical Pharmacology (J.Z., C.W.), Novartis, East Hanover, New Jersey 07936.
  • Rebello S; Department of Drug Metabolism and Pharmacokinetics (H.J.E., L.W., S.R.) and Oncology Clinical Pharmacology (J.Z., C.W.), Novartis, East Hanover, New Jersey 07936.
Drug Metab Dispos ; 45(4): 361-374, 2017 04.
Article em En | MEDLINE | ID: mdl-28122787
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piridinas / Compostos de Bifenilo / Simulação por Computador / Indutores do Citocromo P-450 CYP3A / Inibidores do Citocromo P-450 CYP3A / Modelos Biológicos / Neoplasias Tipo de estudo: Clinical_trials / Guideline / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piridinas / Compostos de Bifenilo / Simulação por Computador / Indutores do Citocromo P-450 CYP3A / Inibidores do Citocromo P-450 CYP3A / Modelos Biológicos / Neoplasias Tipo de estudo: Clinical_trials / Guideline / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2017 Tipo de documento: Article