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Glecaprevir and pibrentasvir for 12 weeks for hepatitis C virus genotype 1 infection and prior direct-acting antiviral treatment.
Poordad, Fred; Felizarta, Franco; Asatryan, Armen; Sulkowski, Mark S; Reindollar, Robert W; Landis, Charles S; Gordon, Stuart C; Flamm, Steven L; Fried, Michael W; Bernstein, David E; Lin, Chih-Wei; Liu, Ran; Lovell, Sandra S; Ng, Teresa I; Kort, Jens; Mensa, Federico J.
Afiliação
  • Poordad F; Texas Liver Institute, University of Texas Health Science Center, San Antonio, TX.
  • Felizarta F; Private Practice, Bakersfield, CA.
  • Asatryan A; AbbVie Inc, North Chicago, IL.
  • Sulkowski MS; Johns Hopkins University School of Medicine, Baltimore, MD.
  • Reindollar RW; Piedmont Healthcare/Carolinas Center for Liver Disease, Statesville, NC.
  • Landis CS; Division of Gastroenterology, University of Washington, Seattle, WA.
  • Gordon SC; Henry Ford Health System, Detroit, MI.
  • Flamm SL; Northwestern Feinberg School of Medicine, Chicago, IL.
  • Fried MW; University of North Carolina, Chapel Hill, NC.
  • Bernstein DE; North Shore University Hospital, Manhasset, NY.
  • Lin CW; AbbVie Inc, North Chicago, IL.
  • Liu R; AbbVie Inc, North Chicago, IL.
  • Lovell SS; AbbVie Inc, North Chicago, IL.
  • Ng TI; AbbVie Inc, North Chicago, IL.
  • Kort J; AbbVie Inc, North Chicago, IL.
  • Mensa FJ; AbbVie Inc, North Chicago, IL.
Hepatology ; 66(2): 389-397, 2017 08.
Article em En | MEDLINE | ID: mdl-28128852
Although direct-acting antiviral (DAA) therapies for chronic hepatitis C virus (HCV) infection have demonstrated high rates of sustained virologic response, virologic failure may still occur, potentially leading to the emergence of viral resistance, which can decrease the effectiveness of subsequent treatment. Treatment options for patients who failed previous DAA-containing regimens, particularly those with nonstructural protein 5A inhibitors, are limited and remain an area of unmet medical need. This phase 2, open-label study (MAGELLAN-1) evaluated the efficacy and safety of glecaprevir (GLE) + pibrentasvir (PIB) ± ribavirin (RBV) in HCV genotype 1-infected patients with prior virologic failure to HCV DAA-containing therapy. A total of 50 patients without cirrhosis were randomized to three arms: 200 mg GLE + 80 mg PIB (arm A), 300 mg GLE + 120 mg PIB with 800 mg once-daily RBV (arm B), or 300 mg GLE + 120 mg PIB without RBV (arm C). By intent-to-treat analysis, sustained virologic response at posttreatment week 12 was achieved in 100% (6/6, 95% confidence interval 61-100), 95% (21/22, 95% confidence interval 78-99), and 86% (19/22, 95% confidence interval 67-95) of patients in arms A, B, and C, respectively. Virologic failure occurred in no patients in arm A and in 1 patient each in arms B and C (two patients were lost to follow-up in arm C). The majority of adverse events were mild in severity; no serious adverse events related to study drug and no relevant laboratory abnormalities in alanine aminotransferase, total bilirubin, or hemoglobin were observed. CONCLUSION: The combination of GLE and PIB was highly efficacious and well tolerated in patients with HCV genotype 1 infection and prior failure of DAA-containing therapy; RBV coadministration did not improve efficacy. (Hepatology 2017;66:389-397).
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antivirais / Quinoxalinas / Ribavirina / Sulfonamidas / Benzimidazóis / Interferon-alfa / Hepatite C Crônica Tipo de estudo: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged País como assunto: America do norte Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antivirais / Quinoxalinas / Ribavirina / Sulfonamidas / Benzimidazóis / Interferon-alfa / Hepatite C Crônica Tipo de estudo: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged País como assunto: America do norte Idioma: En Ano de publicação: 2017 Tipo de documento: Article