Prenatal exposure to tobacco smoke sex dependently influences methylation and mRNA levels of the <i>Igf</i> axis in lungs of mouse offspring.

Meyer, K F; Krauss-Etschmann, S; Kooistra, W; Reinders-Luinge, M; Timens, W; Kobzik, L; Plösch, T; Hylkema, M N

Prenatal exposure to tobacco smoke sex dependently influences methylation and mRNA levels of the Igf axis in lungs of mouse offspring.

Meyer, K F; Krauss-Etschmann, S; Kooistra, W; Reinders-Luinge, M; Timens, W; Kobzik, L; Plösch, T; Hylkema, M N.

Afiliação

Meyer KF; Department of Pathology and Medical Biology, University of Groningen, University Medical Center, Groningen, The Netherlands.
Krauss-Etschmann S; GRIAC Research Institute, University of Groningen, University Medical Center Groningen, The Netherlands.
Kooistra W; Priority Area Asthma and Allergy, Leibnitz Center for Medicine and Biosciences, Research Center Borstel and Christian Albrechts University Kiel, Germany.
Reinders-Luinge M; Department of Pathology and Medical Biology, University of Groningen, University Medical Center, Groningen, The Netherlands.
Timens W; GRIAC Research Institute, University of Groningen, University Medical Center Groningen, The Netherlands.
Kobzik L; Department of Pathology and Medical Biology, University of Groningen, University Medical Center, Groningen, The Netherlands.
Plösch T; GRIAC Research Institute, University of Groningen, University Medical Center Groningen, The Netherlands.
Hylkema MN; Department of Pathology and Medical Biology, University of Groningen, University Medical Center, Groningen, The Netherlands.

Am J Physiol Lung Cell Mol Physiol ; 312(4): L542-L555, 2017 Apr 01.

Article em En | MEDLINE | ID: mdl-28130259

Assuntos

Metilação de DNA/genética; Fator de Crescimento Insulin-Like I/genética; Pulmão/metabolismo; Nicotiana/efeitos adversos; Efeitos Tardios da Exposição Pré-Natal/metabolismo; Receptor IGF Tipo 1/genética; Caracteres Sexuais; Transdução de Sinais; Fumar/efeitos adversos; Animais; Animais Recém-Nascidos; Peso Corporal; Ilhas de CpG/genética; Feminino; Fator de Crescimento Insulin-Like I/metabolismo; Masculino; Camundongos Endogâmicos BALB C; Gravidez; Regiões Promotoras Genéticas; RNA Mensageiro/genética; RNA Mensageiro/metabolismo; Receptor IGF Tipo 1/metabolismo; Transdução de Sinais/genética

Palavras-chave

COPD; asthma; developmental origins of health and disease; epigenetics; fetal programming; pyrosequencing

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Efeitos Tardios da Exposição Pré-Natal / Nicotiana / Fator de Crescimento Insulin-Like I / Transdução de Sinais / Fumar / Caracteres Sexuais / Receptor IGF Tipo 1 / Metilação de DNA / Pulmão Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Animals / Pregnancy Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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