Janus kinase inhibitors display broad anti-itch properties: A possible link through the TRPV1 receptor.

Fukuyama, Tomoki; Ganchingco, Joy Rachel; Mishra, Santosh K; Olivry, Thierry; Rzagalinski, Ignacy; Volmer, Dietrich A; Bäumer, Wolfgang

Janus kinase inhibitors display broad anti-itch properties: A possible link through the TRPV1 receptor.

Fukuyama, Tomoki; Ganchingco, Joy Rachel; Mishra, Santosh K; Olivry, Thierry; Rzagalinski, Ignacy; Volmer, Dietrich A; Bäumer, Wolfgang.

Afiliação

Fukuyama T; Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC; Comparative Medicine Institute, North Carolina State University, Raleigh, NC.
Ganchingco JR; Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC; Comparative Medicine Institute, North Carolina State University, Raleigh, NC.
Mishra SK; Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC; Comparative Medicine Institute, North Carolina State University, Raleigh, NC.
Olivry T; Comparative Medicine Institute, North Carolina State University, Raleigh, NC; Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC.
Rzagalinski I; Institute of Bioanalytical Chemistry, Saarland University, Saarbrücken, Germany.
Volmer DA; Institute of Bioanalytical Chemistry, Saarland University, Saarbrücken, Germany.
Bäumer W; Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC; Comparative Medicine Institute, North Carolina State University, Raleigh, NC. Electronic address: wolfgang_baeumer@ncsu.edu.

J Allergy Clin Immunol ; 140(1): 306-309.e3, 2017 07.

Article em En | MEDLINE | ID: mdl-28131799

Assuntos

Antipruriginosos/farmacologia; Inibidores de Janus Quinases/farmacologia; Canais de Cátion TRPV/antagonistas & inibidores; Animais; Antipruriginosos/química; Neurônios Dopaminérgicos/efeitos dos fármacos; Neurônios Dopaminérgicos/metabolismo; Feminino; Humanos; Inibidores de Janus Quinases/química; Camundongos; Modelos Moleculares; Conformação Molecular; Imagem Molecular/métodos; Ligação Proteica; Células Receptoras Sensoriais/efeitos dos fármacos; Células Receptoras Sensoriais/metabolismo; Relação Estrutura-Atividade; Canais de Cátion TRPV/química; Canais de Cátion TRPV/metabolismo

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Canais de Cátion TRPV / Inibidores de Janus Quinases / Antipruriginosos Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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