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Building ProteomeTools based on a complete synthetic human proteome.
Zolg, Daniel P; Wilhelm, Mathias; Schnatbaum, Karsten; Zerweck, Johannes; Knaute, Tobias; Delanghe, Bernard; Bailey, Derek J; Gessulat, Siegfried; Ehrlich, Hans-Christian; Weininger, Maximilian; Yu, Peng; Schlegl, Judith; Kramer, Karl; Schmidt, Tobias; Kusebauch, Ulrike; Deutsch, Eric W; Aebersold, Ruedi; Moritz, Robert L; Wenschuh, Holger; Moehring, Thomas; Aiche, Stephan; Huhmer, Andreas; Reimer, Ulf; Kuster, Bernhard.
Afiliação
  • Zolg DP; Chair of Proteomics and Bioanalytics, Technical University of Munich, Freising, Germany.
  • Wilhelm M; Chair of Proteomics and Bioanalytics, Technical University of Munich, Freising, Germany.
  • Schnatbaum K; JPT Peptide Technologies GmbH, Berlin, Germany.
  • Zerweck J; JPT Peptide Technologies GmbH, Berlin, Germany.
  • Knaute T; JPT Peptide Technologies GmbH, Berlin, Germany.
  • Delanghe B; Thermo Fisher Scientific, Bremen, Germany.
  • Bailey DJ; Thermo Fisher Scientific, San Jose, California, USA.
  • Gessulat S; Chair of Proteomics and Bioanalytics, Technical University of Munich, Freising, Germany.
  • Ehrlich HC; SAP SE, Potsdam, Germany.
  • Weininger M; SAP SE, Potsdam, Germany.
  • Yu P; Chair of Proteomics and Bioanalytics, Technical University of Munich, Freising, Germany.
  • Schlegl J; Chair of Proteomics and Bioanalytics, Technical University of Munich, Freising, Germany.
  • Kramer K; SAP SE, Walldorf, Germany.
  • Schmidt T; Chair of Proteomics and Bioanalytics, Technical University of Munich, Freising, Germany.
  • Kusebauch U; Chair of Proteomics and Bioanalytics, Technical University of Munich, Freising, Germany.
  • Deutsch EW; Institute for Systems Biology, Seattle, Washington, USA.
  • Aebersold R; Institute for Systems Biology, Seattle, Washington, USA.
  • Moritz RL; Department of Biology, Institute of Molecular Systems Biology, ETH, Zürich, Switzerland.
  • Wenschuh H; Faculty of Science, University of Zürich, Zürich, Switzerland.
  • Moehring T; Institute for Systems Biology, Seattle, Washington, USA.
  • Aiche S; JPT Peptide Technologies GmbH, Berlin, Germany.
  • Huhmer A; Thermo Fisher Scientific, Bremen, Germany.
  • Reimer U; SAP SE, Potsdam, Germany.
  • Kuster B; Thermo Fisher Scientific, San Jose, California, USA.
Nat Methods ; 14(3): 259-262, 2017 03.
Article em En | MEDLINE | ID: mdl-28135259
ABSTRACT
We describe ProteomeTools, a project building molecular and digital tools from the human proteome to facilitate biomedical research. Here we report the generation and multimodal liquid chromatography-tandem mass spectrometry analysis of >330,000 synthetic tryptic peptides representing essentially all canonical human gene products, and we exemplify the utility of these data in several applications. The resource (available at http//www.proteometools.org) will be extended to >1 million peptides, and all data will be shared with the community via ProteomicsDB and ProteomeXchange.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cromatografia Líquida / Proteoma / Proteômica / Espectrometria de Massas em Tandem Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cromatografia Líquida / Proteoma / Proteômica / Espectrometria de Massas em Tandem Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article