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Elabela/Toddler Is an Endogenous Agonist of the Apelin APJ Receptor in the Adult Cardiovascular System, and Exogenous Administration of the Peptide Compensates for the Downregulation of Its Expression in Pulmonary Arterial Hypertension.
Yang, Peiran; Read, Cai; Kuc, Rhoda E; Buonincontri, Guido; Southwood, Mark; Torella, Rubben; Upton, Paul D; Crosby, Alexi; Sawiak, Stephen J; Carpenter, T Adrian; Glen, Robert C; Morrell, Nicholas W; Maguire, Janet J; Davenport, Anthony P.
Afiliação
  • Yang P; From Experimental Medicine and Immunotherapeutics, University of Cambridge, Centre for Clinical Investigation, Addenbrooke's Hospital, UK (P.Y., C.R., R.E.K., J.J.M., A.P.D.); Wolfson Brain Imaging Centre, Department of Clinical Neuroscience, University of Cambridge, UK (G.B., S.J.S., T.A.C.); Depar
  • Read C; From Experimental Medicine and Immunotherapeutics, University of Cambridge, Centre for Clinical Investigation, Addenbrooke's Hospital, UK (P.Y., C.R., R.E.K., J.J.M., A.P.D.); Wolfson Brain Imaging Centre, Department of Clinical Neuroscience, University of Cambridge, UK (G.B., S.J.S., T.A.C.); Depar
  • Kuc RE; From Experimental Medicine and Immunotherapeutics, University of Cambridge, Centre for Clinical Investigation, Addenbrooke's Hospital, UK (P.Y., C.R., R.E.K., J.J.M., A.P.D.); Wolfson Brain Imaging Centre, Department of Clinical Neuroscience, University of Cambridge, UK (G.B., S.J.S., T.A.C.); Depar
  • Buonincontri G; From Experimental Medicine and Immunotherapeutics, University of Cambridge, Centre for Clinical Investigation, Addenbrooke's Hospital, UK (P.Y., C.R., R.E.K., J.J.M., A.P.D.); Wolfson Brain Imaging Centre, Department of Clinical Neuroscience, University of Cambridge, UK (G.B., S.J.S., T.A.C.); Depar
  • Southwood M; From Experimental Medicine and Immunotherapeutics, University of Cambridge, Centre for Clinical Investigation, Addenbrooke's Hospital, UK (P.Y., C.R., R.E.K., J.J.M., A.P.D.); Wolfson Brain Imaging Centre, Department of Clinical Neuroscience, University of Cambridge, UK (G.B., S.J.S., T.A.C.); Depar
  • Torella R; From Experimental Medicine and Immunotherapeutics, University of Cambridge, Centre for Clinical Investigation, Addenbrooke's Hospital, UK (P.Y., C.R., R.E.K., J.J.M., A.P.D.); Wolfson Brain Imaging Centre, Department of Clinical Neuroscience, University of Cambridge, UK (G.B., S.J.S., T.A.C.); Depar
  • Upton PD; From Experimental Medicine and Immunotherapeutics, University of Cambridge, Centre for Clinical Investigation, Addenbrooke's Hospital, UK (P.Y., C.R., R.E.K., J.J.M., A.P.D.); Wolfson Brain Imaging Centre, Department of Clinical Neuroscience, University of Cambridge, UK (G.B., S.J.S., T.A.C.); Depar
  • Crosby A; From Experimental Medicine and Immunotherapeutics, University of Cambridge, Centre for Clinical Investigation, Addenbrooke's Hospital, UK (P.Y., C.R., R.E.K., J.J.M., A.P.D.); Wolfson Brain Imaging Centre, Department of Clinical Neuroscience, University of Cambridge, UK (G.B., S.J.S., T.A.C.); Depar
  • Sawiak SJ; From Experimental Medicine and Immunotherapeutics, University of Cambridge, Centre for Clinical Investigation, Addenbrooke's Hospital, UK (P.Y., C.R., R.E.K., J.J.M., A.P.D.); Wolfson Brain Imaging Centre, Department of Clinical Neuroscience, University of Cambridge, UK (G.B., S.J.S., T.A.C.); Depar
  • Carpenter TA; From Experimental Medicine and Immunotherapeutics, University of Cambridge, Centre for Clinical Investigation, Addenbrooke's Hospital, UK (P.Y., C.R., R.E.K., J.J.M., A.P.D.); Wolfson Brain Imaging Centre, Department of Clinical Neuroscience, University of Cambridge, UK (G.B., S.J.S., T.A.C.); Depar
  • Glen RC; From Experimental Medicine and Immunotherapeutics, University of Cambridge, Centre for Clinical Investigation, Addenbrooke's Hospital, UK (P.Y., C.R., R.E.K., J.J.M., A.P.D.); Wolfson Brain Imaging Centre, Department of Clinical Neuroscience, University of Cambridge, UK (G.B., S.J.S., T.A.C.); Depar
  • Morrell NW; From Experimental Medicine and Immunotherapeutics, University of Cambridge, Centre for Clinical Investigation, Addenbrooke's Hospital, UK (P.Y., C.R., R.E.K., J.J.M., A.P.D.); Wolfson Brain Imaging Centre, Department of Clinical Neuroscience, University of Cambridge, UK (G.B., S.J.S., T.A.C.); Depar
  • Maguire JJ; From Experimental Medicine and Immunotherapeutics, University of Cambridge, Centre for Clinical Investigation, Addenbrooke's Hospital, UK (P.Y., C.R., R.E.K., J.J.M., A.P.D.); Wolfson Brain Imaging Centre, Department of Clinical Neuroscience, University of Cambridge, UK (G.B., S.J.S., T.A.C.); Depar
  • Davenport AP; From Experimental Medicine and Immunotherapeutics, University of Cambridge, Centre for Clinical Investigation, Addenbrooke's Hospital, UK (P.Y., C.R., R.E.K., J.J.M., A.P.D.); Wolfson Brain Imaging Centre, Department of Clinical Neuroscience, University of Cambridge, UK (G.B., S.J.S., T.A.C.); Depar
Circulation ; 135(12): 1160-1173, 2017 Mar 21.
Article em En | MEDLINE | ID: mdl-28137936
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hormônios Peptídicos / Hipertensão Pulmonar Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hormônios Peptídicos / Hipertensão Pulmonar Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2017 Tipo de documento: Article