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Regulation of Marginal Zone B-Cell Differentiation by MicroRNA-146a.
King, Jennifer K; Ung, Nolan M; Paing, May H; Contreras, Jorge R; Alberti, Michael O; Fernando, Thilini R; Zhang, Kelvin; Pellegrini, Matteo; Rao, Dinesh S.
Afiliação
  • King JK; Division of Rheumatology and STAR Program, Department of Medicine, University of California Los Angeles, Los Angeles, CA, USA; Cellular and Molecular Pathology Ph.D.Program, Department of Pathology and Laboratory Medicine, University of California, Los Angeles, CA, USA.
  • Ung NM; Department of Pathology and Laboratory Medicine, University of California Los Angeles , Los Angeles, CA , USA.
  • Paing MH; Department of Pathology and Laboratory Medicine, University of California Los Angeles , Los Angeles, CA , USA.
  • Contreras JR; Cellular and Molecular Pathology Ph.D.Program, Department of Pathology and Laboratory Medicine, University of California, Los Angeles, CA, USA; Department of Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, CA, USA.
  • Alberti MO; Department of Pathology and Laboratory Medicine, University of California Los Angeles , Los Angeles, CA , USA.
  • Fernando TR; Department of Pathology and Laboratory Medicine, University of California Los Angeles , Los Angeles, CA , USA.
  • Zhang K; Department of Biological Chemistry, University of California Los Angeles, Los Angeles, CA, USA; Howard Hughes Medical Institute, University of California Los Angeles, Los Angeles, CA, USA.
  • Pellegrini M; Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, CA, USA; Molecular Cell and Developmental Biology, University of California Los Angeles, Los Angeles, CA, USA; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California
  • Rao DS; Department of Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, CA, USA; Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, CA, USA; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of Cal
Front Immunol ; 7: 670, 2016.
Article em En | MEDLINE | ID: mdl-28138326
B-cell development in the bone marrow is followed by specification into functional subsets in the spleen, including marginal zone (MZ) B-cells. MZ B-cells are classically characterized by T-independent antigenic responses and require the elaboration of distinct gene expression programs for development. Given their role in gene regulation, it is not surprising that microRNAs are important factors in B-cell development. Recent work demonstrated that deficiency of the NFκB feedback regulator, miR-146a, led to a range of hematopoietic phenotypes, but B-cell phenotypes have not been extensively characterized. Here, we found that miR-146a-deficient mice demonstrate a reduction in MZ B-cells, likely from a developmental block. Utilizing high-throughput sequencing and comparative analysis of developmental stage-specific transcriptomes, we determined that MZ cell differentiation was impaired due to decreases in Notch2 signaling. Our studies reveal miR-146a-dependent B-cell phenotypes and highlight the complex role of miR-146a in the hematopoietic system.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2016 Tipo de documento: Article