Increased insular connectivity with emotional regions in primary insomnia patients: a resting-state fMRI study.
Eur Radiol
; 27(9): 3703-3709, 2017 Sep.
Article
em En
| MEDLINE
| ID: mdl-28144739
ABSTRACT
OBJECTIVE:
To explore the abnormal connectivity patterns between the insular and the voxels of the brain in primary insomnia (PI) with insular-based functional connectivity (FC).METHODS:
With the resting-state fMRI data acquired from 57 PI patients and 46 healthy controls, a two-sample t test was performed on individual FC correlation maps from two groups. The person correlation analysis was used to evaluate the relationship between the abnormal FC and clinical features.RESULTS:
PI patients show enhanced connectivity between the left insula with the right anterior cingulate cortex (p < 0.05 and p < 0.001, AlphaSim-corrected), right frontal sup orb, bilateral thalamus and left precuneus,as well as decreased connectivity with the left middle temporal gyrus and right fusiform (p < 0.05, AlphaSim-corrected). Correlation analysis indicated the enhanced connectivities in the PI patients have significant negative correlations with Self-Rating Depression Scale(SDS)and Self-Rating Anxiety Scale(SAS)scores. In addition, the decreased functional connectivities showed positive correlations with SDS and SAS scores.CONCLUSION:
Our study showed the increased connectivity regions with insula were mainly in the emotional circle and decreased connectivity was in cognitive-related regions. These provide additional evidence from functional integration view to understand the possible underlying neural- mechanisms of PI. KEY POINTS ⢠The aberrant insular-based connectivity pattern of PI patients was detected. ⢠Regions showing increased connectivity with left insular were mainly in emotional circle. ⢠Significant correlations between changed FC and SDS and SAS score were found.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Encéfalo
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Mapeamento Encefálico
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Imageamento por Ressonância Magnética
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Conectoma
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Distúrbios do Início e da Manutenção do Sono
Tipo de estudo:
Observational_studies
Limite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article