Bioactive steroids and sorbicillinoids isolated from the endophytic fungus Trichoderma sp. Xy24.
J Asian Nat Prod Res
; 19(10): 1028-1035, 2017 Oct.
Article
em En
| MEDLINE
| ID: mdl-28145126
ABSTRACT
A new steroid glucoside (1), along with nine known steroids (2-10) and four known sorbicillinoids (11-14), were isolated from the endophytic fungus Trichoderma sp. Xy24. Their structures were elucidated on the basis of spectroscopic data analyses and by comparison with reported data. Compounds 3, 5-7, 9, 10, and 13 exhibited significant inhibitory effects on HIV-1 virus with IC50 values ranging 1.9-9.3 µM; compounds 10, 13, and 14 showed potent inhibitory activity on LPS-induced NO production in BV2 microglia cells with inhibitory rates of 108.2, 100, and 75.1% at 10 µM, respectively. In addition, compound 10 displayed moderate cytotoxicity against BCG823 and HePG2 cell lines with IC50 values of 11.1 and 17.7 µM, respectively.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Esteroides
/
Trichoderma
/
Glucosídeos
Limite:
Humans
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article