Micro-connectomics: probing the organization of neuronal networks at the cellular scale.
Nat Rev Neurosci
; 18(3): 131-146, 2017 03.
Article
em En
| MEDLINE
| ID: mdl-28148956
ABSTRACT
Defining the organizational principles of neuronal networks at the cellular scale, or micro-connectomics, is a key challenge of modern neuroscience. In this Review, we focus on graph theoretical parameters of micro-connectome topology, often informed by economical principles that conceptually originated with Ramón y Cajal's conservation laws. First, we summarize results from studies in intact small organisms and in samples from larger nervous systems. We then evaluate the evidence for an economical trade-off between biological cost and functional value in the organization of neuronal networks. Various results suggest that many aspects of neuronal network organization are indeed the outcome of competition between these two fundamental selection pressures.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
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Conectoma
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Modelos Neurológicos
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Vias Neurais
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Neurônios
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article