Metformin-SGLT2, Dehydration, and Acidosis Potential.

D'Elia, John A; Segal, Alissa R; Weinrauch, Larry A

D'Elia, John A; Segal, Alissa R; Weinrauch, Larry A.

Afiliação

D'Elia JA; Kidney and Hypertension Section, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts.
Segal AR; Kidney and Hypertension Section, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts.
Weinrauch LA; Department of Pharmacy Practice, MCPHS University, Boston, Massachusetts.

J Am Geriatr Soc ; 65(5): e101-e102, 2017 May.

Article em En | MEDLINE | ID: mdl-28152176

RESUMO

Clinicians are aware of the risks and benefits of metformin in type 2 diabetes. In geriatric populations lactic acidosis due to diminishing kidney function is an issue. The recent addition of a group of agents to control diabetes through increased glycosuria may increase the risk of dehydration and acidosis. This may happen due to gastrointestinal loss from metformin diarrhea or urine loss from diuretics. A typical example is presented.

Assuntos

Acidose Láctica/etiologia; Desidratação/etiologia; Hipoglicemiantes/efeitos adversos; Metformina/efeitos adversos; Idoso de 80 Anos ou mais; Diabetes Mellitus Tipo 2/tratamento farmacológico; Humanos; Hipoglicemiantes/uso terapêutico; Masculino; Metformina/uso terapêutico; Fatores de Risco

Palavras-chave

SGLT-2 inhibitors; acidosis; dehydration; metformin

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Acidose Láctica / Desidratação / Hipoglicemiantes / Metformina Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Aged80 / Humans / Male Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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