[The "immune checkpoints", how does it work]. / Les « immune checkpoints ¼, comment ça marche.
Ann Pathol
; 37(1): 18-28, 2017 Feb.
Article
em Fr
| MEDLINE
| ID: mdl-28160999
ABSTRACT
Costimulatory molecules allow the full lymphocyte activation, whereas co-inhibitory molecules are negative counterparts that act as immune regulators, avoiding excessive response. In some context of chronic inflammation such as cancer, co-inhibitory immune checkpoint as CTLA-4, PD-1, Lag-3, Tim-3 can accumulate at the membrane of T cells leading to a state of anergy and therefore the loss of tumor growth control. Consequently, these immune checkpoints are considered as potential target in the treatment of cancer. Immunotherapy by anti-CTLA-4 and anti-PD-1/PD-L1 early demonstrated very good proof of efficacy in the setting of several cancers types, supporting the role of these molecules in tumor immune escape. The aim of this review is to summarize the pathophysiology of immune checkpoints and their therapeutic applications in cancer.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ativação Linfocitária
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Subpopulações de Linfócitos T
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Antígeno B7-H1
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Antígeno CTLA-4
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Receptor de Morte Celular Programada 1
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Proteínas de Neoplasias
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Neoplasias
Limite:
Humans
Idioma:
Fr
Ano de publicação:
2017
Tipo de documento:
Article