Englerins: A Comprehensive Review.

Wu, Zhenhua; Zhao, Senzhi; Fash, David M; Li, Zhenwu; Chain, William J; Beutler, John A

Wu, Zhenhua; Zhao, Senzhi; Fash, David M; Li, Zhenwu; Chain, William J; Beutler, John A.

Afiliação

Wu Z; Department of Chemistry and Biochemistry, University of Delaware , Newark, Delaware 19716, United States.
Zhao S; Department of Chemistry and Biochemistry, University of Delaware , Newark, Delaware 19716, United States.
Fash DM; Department of Chemistry and Biochemistry, University of Delaware , Newark, Delaware 19716, United States.
Li Z; Department of Chemistry and Biochemistry, University of Delaware , Newark, Delaware 19716, United States.
Chain WJ; Department of Chemistry and Biochemistry, University of Delaware , Newark, Delaware 19716, United States.
Beutler JA; Molecular Targets Laboratory, Center for Cancer Research, National Cancer Institute , Frederick, Maryland 21702, United States.

J Nat Prod ; 80(3): 771-781, 2017 03 24.

Article em En | MEDLINE | ID: mdl-28170253

ABSTRACT

ABSTRACT

In the decade since the discovery of englerin A (1) and its potent activity in cancer models, this natural product and its analogues have been the subject of numerous chemical, biological, and preclinical studies by many research groups. This review summarizes published findings and proposes further research directions required for entry of an englerin analogue into clinical trials for kidney cancer and other conditions.

Assuntos

Antineoplásicos Fitogênicos; Neoplasias Renais/tratamento farmacológico; Sesquiterpenos de Guaiano; Humanos; Estrutura Molecular

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sesquiterpenos de Guaiano / Neoplasias Renais / Antineoplásicos Fitogênicos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google