Hypoxia Positively Regulates the Expression of pH-Sensing G-Protein-Coupled Receptor OGR1 (GPR68).

de Vallière, Cheryl; Cosin-Roger, Jesus; Simmen, Simona; Atrott, Kirstin; Melhem, Hassan; Zeitz, Jonas; Madanchi, Mehdi; Tcymbarevich, Irina; Fried, Michael; Kullak-Ublick, Gerd A; Vavricka, Stephan R; Misselwitz, Benjamin; Seuwen, Klaus; Wagner, Carsten A; Eloranta, Jyrki J; Rogler, Gerhard; Ruiz, Pedro A

de Vallière, Cheryl; Cosin-Roger, Jesus; Simmen, Simona; Atrott, Kirstin; Melhem, Hassan; Zeitz, Jonas; Madanchi, Mehdi; Tcymbarevich, Irina; Fried, Michael; Kullak-Ublick, Gerd A; Vavricka, Stephan R; Misselwitz, Benjamin; Seuwen, Klaus; Wagner, Carsten A; Eloranta, Jyrki J; Rogler, Gerhard; Ruiz, Pedro A.

Afiliação

de Vallière C; Division of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland.
Cosin-Roger J; Division of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland; Department of Pharmacology and Biomedical Research Networking Center in Hepatic and Digestive Diseases (CIBERehd), Faculty of Medicine, University of Valencia, Valencia, Spain.
Simmen S; Division of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland.
Atrott K; Division of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland.
Melhem H; Division of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland.
Zeitz J; Division of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland.
Madanchi M; Division of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland.
Tcymbarevich I; Division of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland.
Fried M; Division of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland.
Kullak-Ublick GA; Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, Zurich, Switzerland.
Vavricka SR; Division of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland.
Misselwitz B; Division of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland.
Seuwen K; Novartis Institutes for Biomedical Research, Basel, Switzerland.
Wagner CA; Institute of Physiology, University Hospital Zurich, Zurich, Switzerland.
Eloranta JJ; Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, Zurich, Switzerland.
Rogler G; Division of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland.
Ruiz PA; Division of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland.

Cell Mol Gastroenterol Hepatol ; 2(6): 796-810, 2016 Nov.

Article em En | MEDLINE | ID: mdl-28174749

Palavras-chave

AICAR, 5-aminoimidazole-4-carboxamide-1-ß-4-ribofuranoside; CD, Crohn's disease; ChIP, chromatin immunoprecipitation; FCS, fetal calf serum; GPR, G-proteincoupled receptor; GRP65; HIF, hypoxia-inducible factor; HV, healthy volunteer; IBD, inflammatory bowel disease; IEC, intestinal epithelial cell; IFN, interferon; IL, interleukin; Inflammation; Inflammatory Bowel Disease; MM6, MonoMac 6; NF-κB, nuclear factor-κB; OGR1, ovarian cancer G-proteincoupled receptor 1 (GPR68); Ovarian Cancer G-ProteinCoupled Receptor; RT-qPCR, quantitative reverse-transcription polymerase chain reaction; SPARC, secreted protein acidic and rich in cysteine; TDAG8; TDAG8, T-cell death-associated gene 8 (GPR65); TNF, tumor necrosis factor; Th, T-helper; UC, ulcerative colitis; WT, wild type; mRNA, messenger RNA

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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2016 Tipo de documento: Article