Monitoring of somatic mutations in circulating cell-free DNA by digital PCR and next-generation sequencing during afatinib treatment in patients with lung adenocarcinoma positive for EGFR activating mutations.

Iwama, E; Sakai, K; Azuma, K; Harada, T; Harada, D; Nosaki, K; Hotta, K; Ohyanagi, F; Kurata, T; Fukuhara, T; Akamatsu, H; Goto, K; Shimose, T; Kishimoto, J; Nakanishi, Y; Nishio, K; Okamoto, I

Iwama, E; Sakai, K; Azuma, K; Harada, T; Harada, D; Nosaki, K; Hotta, K; Ohyanagi, F; Kurata, T; Fukuhara, T; Akamatsu, H; Goto, K; Shimose, T; Kishimoto, J; Nakanishi, Y; Nishio, K; Okamoto, I.

Afiliação

Iwama E; Department of Comprehensive Clinical Oncology, Faculty of Medical Sciences, Kyushu University, Fukuoka.
Sakai K; Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka.
Azuma K; Department of Genome Biology, Kinki University Faculty of Medicine, Osaka-Sayama.
Harada T; Division of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, Kurume.
Harada D; Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka.
Nosaki K; Department of Thoracic Oncology, NHO Shikoku Cancer Center, Matsuyama.
Hotta K; Department of Thoracic Oncology, National Kyushu Cancer Center, Fukuoka.
Ohyanagi F; Center for Innovative Clinical Medicine, Okayama University Hospital, Okayama.
Kurata T; Department of Thoracic Medical Oncology, Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo.
Fukuhara T; Department of Thoracic Oncology, Kansai Medical University Hospital, Hirakata.
Akamatsu H; Department of Respiratory Medicine, Miyagi Cancer Center, Natori.
Goto K; Third Department of Internal Medicine, Wakayama Medical University, Wakayama.
Shimose T; Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa.
Kishimoto J; Clinical Research Support Center Kyushu, Fukuoka.
Nakanishi Y; Department of Research and Development of Next Generation Medicine, Kyushu University, Fukuoka, Japan.
Nishio K; Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka.
Okamoto I; Department of Genome Biology, Kinki University Faculty of Medicine, Osaka-Sayama.

Ann Oncol ; 28(1): 136-141, 2017 01 01.

Article em En | MEDLINE | ID: mdl-28177428

Assuntos

Adenocarcinoma/tratamento farmacológico; Adenocarcinoma/genética; DNA Tumoral Circulante/genética; Receptores ErbB/genética; Neoplasias Pulmonares/tratamento farmacológico; Neoplasias Pulmonares/genética; Mutação; Quinazolinas/uso terapêutico; Adenocarcinoma/sangue; Adenocarcinoma/enzimologia; Adenocarcinoma de Pulmão; Afatinib; DNA Tumoral Circulante/sangue; Receptores ErbB/metabolismo; Feminino; Sequenciamento de Nucleotídeos em Larga Escala/métodos; Humanos; Biópsia Líquida; Neoplasias Pulmonares/sangue; Neoplasias Pulmonares/enzimologia; Masculino; Estadiamento de Neoplasias; Reação em Cadeia da Polimerase/métodos; Estudos Prospectivos; Quinazolinas/efeitos adversos

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Quinazolinas / Adenocarcinoma / Receptores ErbB / DNA Tumoral Circulante / Neoplasias Pulmonares / Mutação Tipo de estudo: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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