MALAT1 is a prognostic factor in glioblastoma multiforme and induces chemoresistance to temozolomide through suppressing miR-203 and promoting thymidylate synthase expression.

Chen, Wei; Xu, Xin-Ke; Li, Jun-Liang; Kong, Kuan-Kei; Li, Hui; Chen, Cheng; He, Jing; Wang, Fangyu; Li, Ping; Ge, Xiao-Song; Li, Fang-Cheng

Chen, Wei; Xu, Xin-Ke; Li, Jun-Liang; Kong, Kuan-Kei; Li, Hui; Chen, Cheng; He, Jing; Wang, Fangyu; Li, Ping; Ge, Xiao-Song; Li, Fang-Cheng.

Afiliação

Chen W; Department of Neurosurgery, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, China.
Xu XK; Department of Neurosurgery, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China.
Li JL; State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China.
Kong KK; Department of Neurosurgery, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, China.
Li H; Department of Neurosurgery, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, China.
Chen C; Department of Neurosurgery, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China.
He J; Department of Neurosurgery, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, China.
Wang F; Department of Neurosurgery, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China.
Li P; Department of Respiratory, The First People's Hospital of Foshan, Sun Yat-Sen University, Guangdong Foshan 528000, China.
Ge XS; Department of Neurosurgery, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, China.
Li FC; Department of Neurosurgery, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, China.

Oncotarget ; 8(14): 22783-22799, 2017 Apr 04.

Article em En | MEDLINE | ID: mdl-28187000

Assuntos

Neoplasias Encefálicas/patologia; Dacarbazina/análogos & derivados; Resistencia a Medicamentos Antineoplásicos/genética; Glioblastoma/patologia; MicroRNAs/genética; RNA Longo não Codificante/genética; Timidilato Sintase/metabolismo; Antineoplásicos Alquilantes/farmacologia; Apoptose/efeitos dos fármacos; Biomarcadores Tumorais/genética; Biomarcadores Tumorais/metabolismo; Neoplasias Encefálicas/tratamento farmacológico; Neoplasias Encefálicas/genética; Neoplasias Encefálicas/metabolismo; Ciclo Celular/efeitos dos fármacos; Proliferação de Células/efeitos dos fármacos; Dacarbazina/farmacologia; Regulação Neoplásica da Expressão Gênica; Glioblastoma/tratamento farmacológico; Glioblastoma/genética; Glioblastoma/metabolismo; Humanos; Estadiamento de Neoplasias; Prognóstico; Taxa de Sobrevida; Temozolomida; Timidilato Sintase/genética; Células Tumorais Cultivadas

Palavras-chave

MALAT1; chemoresistance; miR-203; temozolomide; thymidylate synthase

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Timidilato Sintase / Neoplasias Encefálicas / Glioblastoma / Resistencia a Medicamentos Antineoplásicos / Dacarbazina / MicroRNAs / RNA Longo não Codificante Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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