Retinoic acid and TGF-ß signalling cooperate to overcome MYCN-induced retinoid resistance.

Duffy, David J; Krstic, Aleksandar; Halasz, Melinda; Schwarzl, Thomas; Konietzny, Anja; Iljin, Kristiina; Higgins, Desmond G; Kolch, Walter

Duffy, David J; Krstic, Aleksandar; Halasz, Melinda; Schwarzl, Thomas; Konietzny, Anja; Iljin, Kristiina; Higgins, Desmond G; Kolch, Walter.

Afiliação

Duffy DJ; Systems Biology Ireland, University College Dublin, Belfield, Dublin 4, Ireland. duffy@whitney.ufl.edu.
Krstic A; Conway Institute of Biomolecular & Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland. duffy@whitney.ufl.edu.
Halasz M; School of Medicine, University College Dublin, Belfield, Dublin 4, Ireland. duffy@whitney.ufl.edu.
Schwarzl T; The Whitney Laboratory for Marine Bioscience and Sea Turtle Hospital, University of Florida, St. Augustine, Florida, 32080, USA. duffy@whitney.ufl.edu.
Konietzny A; Systems Biology Ireland, University College Dublin, Belfield, Dublin 4, Ireland.
Iljin K; Conway Institute of Biomolecular & Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland.
Higgins DG; School of Medicine, University College Dublin, Belfield, Dublin 4, Ireland.
Kolch W; Systems Biology Ireland, University College Dublin, Belfield, Dublin 4, Ireland.

Genome Med ; 9(1): 15, 2017 02 10.

Article em En | MEDLINE | ID: mdl-28187790

Assuntos

Anilidas/uso terapêutico; Proteína Proto-Oncogênica N-Myc/efeitos dos fármacos; Neuroblastoma/tratamento farmacológico; Ácidos Ftálicos/uso terapêutico; Transdução de Sinais; Fator de Crescimento Transformador beta/efeitos dos fármacos; Tretinoína/uso terapêutico; Antineoplásicos/uso terapêutico; Linhagem Celular Tumoral; Resistencia a Medicamentos Antineoplásicos; Regulação Neoplásica da Expressão Gênica; Humanos; Neuroblastoma/genética; Neuroblastoma/metabolismo; Medicina de Precisão; Retinoides/uso terapêutico

Palavras-chave

Cancer; ChIP sequencing (ChIP-seq); Differentiation; Differentiation therapy; Genome medicine; Interaction proteomics; Kartogenin (KGN); MYC (c-MYC); Neuroblastoma; Neuronal differentiation; Precision medicine; RepSox; Systems medicine; Transforming growth factor beta (TGF-ß) signalling; Wnt ß-catenin signalling; mRNA sequencing (mRNA-seq)

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ácidos Ftálicos / Tretinoína / Transdução de Sinais / Fator de Crescimento Transformador beta / Proteína Proto-Oncogênica N-Myc / Anilidas / Neuroblastoma Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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