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Lectin pathway effector enzyme mannan-binding lectin-associated serine protease-2 can activate native complement C3 in absence of C4 and/or C2.
Yaseen, Sadam; Demopulos, Gregory; Dudler, Thomas; Yabuki, Munehisa; Wood, Christi L; Cummings, W Jason; Tjoelker, Larry W; Fujita, Teizo; Sacks, Steven; Garred, Peter; Andrew, Peter; Sim, Robert B; Lachmann, Peter J; Wallis, Russell; Lynch, Nicholas; Schwaeble, Wilhelm J.
Afiliação
  • Yaseen S; Department of Infection, Immunity, and Inflammation, University of Leicester, Leicester, United Kingdom.
  • Demopulos G; Omeros Corporation, Seattle, Washington, USA.
  • Dudler T; Department of Biology, University of Mosul, Mosul, Iraq.
  • Yabuki M; Omeros Corporation, Seattle, Washington, USA.
  • Wood CL; Omeros Corporation, Seattle, Washington, USA.
  • Cummings WJ; Omeros Corporation, Seattle, Washington, USA.
  • Tjoelker LW; Omeros Corporation, Seattle, Washington, USA.
  • Fujita T; Omeros Corporation, Seattle, Washington, USA.
  • Sacks S; Omeros Corporation, Seattle, Washington, USA.
  • Garred P; Fukushima Prefectural General Hygiene Institute, Fukushima Medical University, Fukushima City, Japan.
  • Andrew P; Medical Research Council (MRC) Centre for Transplantation, King's College London, Guy's Campus, London, United Kingdom.
  • Sim RB; Laboratory of Molecular Medicine, Department of Clinical Immunology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
  • Lachmann PJ; Department of Infection, Immunity, and Inflammation, University of Leicester, Leicester, United Kingdom.
  • Wallis R; Department of Infection, Immunity, and Inflammation, University of Leicester, Leicester, United Kingdom.
  • Lynch N; Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom.
  • Schwaeble WJ; Department of Infection, Immunity, and Inflammation, University of Leicester, Leicester, United Kingdom.
FASEB J ; 31(5): 2210-2219, 2017 05.
Article em En | MEDLINE | ID: mdl-28188176

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Complemento C2 / Complemento C3 / Complemento C4 / Ativação do Complemento / Serina Proteases Associadas a Proteína de Ligação a Manose / Lectinas Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Complemento C2 / Complemento C3 / Complemento C4 / Ativação do Complemento / Serina Proteases Associadas a Proteína de Ligação a Manose / Lectinas Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article