<i>THADA</i> fusion is a mechanism of IGF2BP3 activation and IGF1R signaling in thyroid cancer.

Panebianco, Federica; Kelly, Lindsey M; Liu, Pengyuan; Zhong, Shan; Dacic, Sanja; Wang, Xiaosong; Singhi, Aatur D; Dhir, Rajiv; Chiosea, Simion I; Kuan, Shih-Fan; Bhargava, Rohit; Dabbs, David; Trivedi, Sumita; Gandhi, Manoj; Diaz, Rachel; Wald, Abigail I; Carty, Sally E; Ferris, Robert L; Lee, Adrian V; Nikiforova, Marina N; Nikiforov, Yuri E

THADA fusion is a mechanism of IGF2BP3 activation and IGF1R signaling in thyroid cancer.

Panebianco, Federica; Kelly, Lindsey M; Liu, Pengyuan; Zhong, Shan; Dacic, Sanja; Wang, Xiaosong; Singhi, Aatur D; Dhir, Rajiv; Chiosea, Simion I; Kuan, Shih-Fan; Bhargava, Rohit; Dabbs, David; Trivedi, Sumita; Gandhi, Manoj; Diaz, Rachel; Wald, Abigail I; Carty, Sally E; Ferris, Robert L; Lee, Adrian V; Nikiforova, Marina N; Nikiforov, Yuri E.

Afiliação

Panebianco F; Department of Pathology and Laboratory Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213.
Kelly LM; Department of Pathology and Laboratory Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213.
Liu P; Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310058, China.
Zhong S; Department of Pathology and Laboratory Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213.
Dacic S; Department of Pathology and Laboratory Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213.
Wang X; Department of Pathology and Laboratory Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213.
Singhi AD; Department of Pathology and Laboratory Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213.
Dhir R; Department of Pathology and Laboratory Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213.
Chiosea SI; Department of Pathology and Laboratory Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213.
Kuan SF; Department of Pathology and Laboratory Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213.
Bhargava R; Department of Pathology and Laboratory Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213.
Dabbs D; Department of Pathology and Laboratory Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213.
Trivedi S; Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213.
Gandhi M; Affymetrix, Inc., Santa Clara, CA 95051.
Diaz R; Affymetrix, Inc., Santa Clara, CA 95051.
Wald AI; Department of Pathology and Laboratory Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213.
Carty SE; Division of Endocrine Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213.
Ferris RL; Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213.
Lee AV; Department of Pharmacology and Chemical Biology, Women's Cancer Research Center, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213.
Nikiforova MN; Department of Pathology and Laboratory Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213.
Nikiforov YE; Department of Pathology and Laboratory Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213; nikiforovye@upmc.edu.

Proc Natl Acad Sci U S A ; 114(9): 2307-2312, 2017 02 28.

Article em En | MEDLINE | ID: mdl-28193878

Assuntos

Regulação Neoplásica da Expressão Gênica; Proteínas de Neoplasias/genética; Proteínas de Fusão Oncogênica/genética; Proteínas de Ligação a RNA/genética; Receptores de Somatomedina/genética; Neoplasias da Glândula Tireoide/genética; Animais; Antineoplásicos/farmacologia; Linhagem Celular Tumoral; Transformação Celular Neoplásica; Feminino; Loci Gênicos; Estudo de Associação Genômica Ampla; Humanos; Imidazóis/farmacologia; Fator de Crescimento Insulin-Like II/genética; Fator de Crescimento Insulin-Like II/metabolismo; Camundongos; Camundongos Nus; Proteínas Quinases Ativadas por Mitógeno/genética; Proteínas Quinases Ativadas por Mitógeno/metabolismo; Proteínas de Neoplasias/metabolismo; Proteínas de Fusão Oncogênica/metabolismo; Fosfatidilinositol 3-Quinases/genética; Fosfatidilinositol 3-Quinases/metabolismo; Biossíntese de Proteínas; Inibidores de Proteínas Quinases/farmacologia; Pirazinas/farmacologia; RNA Mensageiro/genética; RNA Mensageiro/metabolismo; Proteínas de Ligação a RNA/metabolismo; Receptor IGF Tipo 1; Receptores de Somatomedina/antagonistas & inibidores; Receptores de Somatomedina/metabolismo; Transdução de Sinais; Neoplasias da Glândula Tireoide/tratamento farmacológico; Neoplasias da Glândula Tireoide/metabolismo; Neoplasias da Glândula Tireoide/patologia; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

IGF1R; IGF2BP3; chromosomal rearrangements; genetics; thyroid cancer

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Glândula Tireoide / Regulação Neoplásica da Expressão Gênica / Proteínas de Fusão Oncogênica / Proteínas de Ligação a RNA / Receptores de Somatomedina / Proteínas de Neoplasias Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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