Platelet uptake of serotonin (5-HT) during ethanol withdrawal in male alcoholics.
Thromb Res
; 46(6): 803-9, 1987 Jun 15.
Article
em En
| MEDLINE
| ID: mdl-2820078
ABSTRACT
Changes in the kinetic variables of the platelet serotonin uptake, Km and Vmax, were studied in 7 male alcoholics, admitted for detoxification and in sex- and age-matched volunteers. On admission the alcoholics had lower Km values than reference subjects (p less than 0.05). During detoxification the Km values normalized. Vmax was normal throughout the study in spite of the changes in platelet count. The results of the study suggest that the affinity of serotonin to its uptake receptor is transiently increased after a period of heavy drinking.
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Base de dados:
MEDLINE
Assunto principal:
Plaquetas
/
Serotonina
/
Etanol
Limite:
Adult
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
1987
Tipo de documento:
Article