Aberrant SYK Kinase Signaling Is Essential for Tumorigenesis Induced by TSC2 Inactivation.

Cui, Ye; Steagall, Wendy K; Lamattina, Anthony M; Pacheco-Rodriguez, Gustavo; Stylianou, Mario; Kidambi, Pranav; Stump, Benjamin; Golzarri, Fernanda; Rosas, Ivan O; Priolo, Carmen; Henske, Elizabeth P; Moss, Joel; El-Chemaly, Souheil

Cui, Ye; Steagall, Wendy K; Lamattina, Anthony M; Pacheco-Rodriguez, Gustavo; Stylianou, Mario; Kidambi, Pranav; Stump, Benjamin; Golzarri, Fernanda; Rosas, Ivan O; Priolo, Carmen; Henske, Elizabeth P; Moss, Joel; El-Chemaly, Souheil.

Afiliação

Cui Y; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Steagall WK; Cardiovascular and Pulmonary Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland.
Lamattina AM; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Pacheco-Rodriguez G; Cardiovascular and Pulmonary Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland.
Stylianou M; Office of Biostatistics Research, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland.
Kidambi P; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Stump B; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Golzarri F; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Rosas IO; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Priolo C; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Henske EP; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Moss J; Cardiovascular and Pulmonary Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland.
El-Chemaly S; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. sel-chemaly@partners.org.

Cancer Res ; 77(6): 1492-1502, 2017 03 15.

Article em En | MEDLINE | ID: mdl-28202529

Assuntos

Biomarcadores Tumorais/metabolismo; Transformação Celular Neoplásica/patologia; Leucócitos Mononucleares/metabolismo; Linfangioleiomiomatose/patologia; Quinase Syk/metabolismo; Proteínas Supressoras de Tumor/antagonistas & inibidores; Animais; Apoptose; Estudos de Casos e Controles; Proliferação de Células; Transformação Celular Neoplásica/genética; Transformação Celular Neoplásica/metabolismo; Células Cultivadas; Quimiocina CCL2/metabolismo; Feminino; Seguimentos; Humanos; Linfangioleiomiomatose/genética; Linfangioleiomiomatose/metabolismo; Camundongos; Camundongos SCID; Mutação/genética; Transdução de Sinais; Proteína 2 do Complexo Esclerose Tuberosa; Proteínas Supressoras de Tumor/genética; Proteínas Supressoras de Tumor/metabolismo; Fator D de Crescimento do Endotélio Vascular/metabolismo; Ensaios Antitumorais Modelo de Xenoenxerto

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Leucócitos Mononucleares / Biomarcadores Tumorais / Transformação Celular Neoplásica / Linfangioleiomiomatose / Proteínas Supressoras de Tumor / Quinase Syk Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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