Valproate Attenuates Endoplasmic Reticulum Stress-Induced Apoptosis in SH-SY5Y Cells via the AKT/GSK3ß Signaling Pathway.

Li, Zhengmao; Wu, Fenzan; Zhang, Xie; Chai, Yi; Chen, Daqing; Yang, Yuetao; Xu, Kebin; Yin, Jiayu; Li, Rui; Shi, Hongxue; Wang, Zhouguang; Li, Xiaokun; Xiao, Jian; Zhang, Hongyu

Li, Zhengmao; Wu, Fenzan; Zhang, Xie; Chai, Yi; Chen, Daqing; Yang, Yuetao; Xu, Kebin; Yin, Jiayu; Li, Rui; Shi, Hongxue; Wang, Zhouguang; Li, Xiaokun; Xiao, Jian; Zhang, Hongyu.

Afiliação

Li Z; Key Laboratory of Biotechnology and Pharmaceutical Engineering, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China. LiZM_YX@163.com.
Wu F; Science and Education division, Cixi People's Hospital, Wenzhou Medical University, Ningbo 315300, China. wufenzan@163.com.
Zhang X; Ningbo Medical Treatment Center, Li Huili Hospital, Ningbo 315000, China. rennie22@126.com.
Chai Y; Department of neurosurgery, The second Affiliated Hospital, Nanchang University, Nanchang 330006, China. lulpls@126.com.
Chen D; Emergency Department, The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou 325035, China. cdq1965@126.com.
Yang Y; Emergency Department, The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou 325035, China. yangyuetao1234@163.com.
Xu K; Key Laboratory of Biotechnology and Pharmaceutical Engineering, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China. xukebin827@163.com.
Yin J; Key Laboratory of Biotechnology and Pharmaceutical Engineering, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China. pashayin@hotmail.com.
Li R; Key Laboratory of Biotechnology and Pharmaceutical Engineering, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China. xiaoerrui1989@163.com.
Shi H; Key Laboratory of Biotechnology and Pharmaceutical Engineering, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China. xue.henwuji@163.com.
Wang Z; Key Laboratory of Biotechnology and Pharmaceutical Engineering, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China. huaikongwang@126.com.
Li X; Key Laboratory of Biotechnology and Pharmaceutical Engineering, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China. xiaokunli@163.com.
Xiao J; Institute of Life Sciences, Wenzhou University, Wenzhou 325035, China. xiaokunli@163.com.
Zhang H; Key Laboratory of Biotechnology and Pharmaceutical Engineering, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China. xfxj2000@126.com.

Int J Mol Sci ; 18(2)2017 Feb 08.

Article em En | MEDLINE | ID: mdl-28208696

Assuntos

Apoptose/efeitos dos fármacos; Estresse do Retículo Endoplasmático/efeitos dos fármacos; Glicogênio Sintase Quinase 3 beta/metabolismo; Proteínas Proto-Oncogênicas c-akt/metabolismo; Transdução de Sinais/efeitos dos fármacos; Ácido Valproico/farmacologia; Linhagem Celular Tumoral; Sobrevivência Celular/efeitos dos fármacos; Chaperona BiP do Retículo Endoplasmático; Humanos; Proteínas Quinases JNK Ativadas por Mitógeno/metabolismo; Metaloproteinase 9 da Matriz/metabolismo; Neurônios/efeitos dos fármacos; Neurônios/metabolismo; Fosforilação; Proteínas Proto-Oncogênicas c-bcl-2/metabolismo; Tapsigargina/farmacologia; Fator de Transcrição CHOP/metabolismo; Proteína X Associada a bcl-2/metabolismo

Palavras-chave

ER stress; apoptosis; neurite outgrowth; neurological disorders; valproate

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Ácido Valproico / Apoptose / Proteínas Proto-Oncogênicas c-akt / Estresse do Retículo Endoplasmático / Glicogênio Sintase Quinase 3 beta Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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