Cell therapy for GI motility disorders: comparison of cell sources and proposed steps for treating Hirschsprung disease.
Am J Physiol Gastrointest Liver Physiol
; 312(4): G348-G354, 2017 Apr 01.
Article
em En
| MEDLINE
| ID: mdl-28209600
ABSTRACT
Cell therapeutic approaches to treat a range of congenital and degenerative neuropathies are under intense investigation. There have been recent significant advancements in the development of cell therapy to treat disorders of the enteric nervous system (ENS), enteric neuropathies. These advances include the efficient generation of enteric neural progenitors from pluripotent stem cells and the rescue of a Hirschsprung disease model mouse following their transplantation into the bowel. Furthermore, a recent study provides evidence of functional innervation of the bowel muscle by neurons derived from transplanted ENS-derived neural progenitors. This mini-review discusses these recent findings, compares endogenous ENS-derived progenitors and pluripotent stem cell-derived progenitors as a cell source for therapy, and proposes the key steps for cell therapy to treat Hirschsprung disease.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Sistema Nervoso Entérico
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Transplante de Células-Tronco
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Células-Tronco Neurais
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Doença de Hirschsprung
Tipo de estudo:
Prognostic_studies
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article