The role of exosomes in cancer metastasis.
Semin Cancer Biol
; 44: 170-181, 2017 06.
Article
em En
| MEDLINE
| ID: mdl-28215970
ABSTRACT
Exosomes are small membrane vesicles with a size ranging from 40 to 100nm. They can serve as functional mediators in cell interaction leading to cancer metastasis. Metastasis is a complex multistep process of cancer cell invasion, survival in blood vessels, attachment to and colonization of the host organ. Exosomes influence every step of this cascade and can be targeted by oncological treatment. This review highlights the role of exosomes in the various steps of the metastatic cascade and how exosome dependent pathways can be targeted as therapeutic approach or used for liquid biopsies.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Exossomos
/
Metástase Neoplásica
/
Neoplasias
Limite:
Humans
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article