Engineering fatty acid synthases for directed polyketide production.
Nat Chem Biol
; 13(4): 363-365, 2017 04.
Article
em En
| MEDLINE
| ID: mdl-28218912
ABSTRACT
In this study, we engineered fatty acid synthases (FAS) for the biosynthesis of short-chain fatty acids and polyketides, guided by a combined in vitro and in silico approach. Along with exploring the synthetic capability of FAS, we aim to build a foundation for efficient protein engineering, with the specific goal of harnessing evolutionarily related megadalton-scale polyketide synthases (PKS) for the tailored production of bioactive natural compounds.
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1
Base de dados:
MEDLINE
Assunto principal:
Engenharia de Proteínas
/
Ácido Graxo Sintases
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Policetídeos
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article