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Engineering fatty acid synthases for directed polyketide production.
Gajewski, Jan; Buelens, Floris; Serdjukow, Sascha; Janßen, Melanie; Cortina, Niña; Grubmüller, Helmut; Grininger, Martin.
Afiliação
  • Gajewski J; Institute of Organic Chemistry and Chemical Biology, Buchmann Institute for Molecular Life Sciences, Cluster of Excellence "Macromolecular Complexes," Goethe University Frankfurt, Frankfurt am Main, Germany.
  • Buelens F; Max Planck Institute for Biophysical Chemistry, Department of Theoretical and Computational Biophysics, Göttingen, Germany.
  • Serdjukow S; Max Planck Institute of Biochemistry, Project Group Biological Chemistry, Martinsried, Germany.
  • Janßen M; Institute of Organic Chemistry and Chemical Biology, Buchmann Institute for Molecular Life Sciences, Cluster of Excellence "Macromolecular Complexes," Goethe University Frankfurt, Frankfurt am Main, Germany.
  • Cortina N; Institute of Organic Chemistry and Chemical Biology, Buchmann Institute for Molecular Life Sciences, Cluster of Excellence "Macromolecular Complexes," Goethe University Frankfurt, Frankfurt am Main, Germany.
  • Grubmüller H; Max Planck Institute for Biophysical Chemistry, Department of Theoretical and Computational Biophysics, Göttingen, Germany.
  • Grininger M; Institute of Organic Chemistry and Chemical Biology, Buchmann Institute for Molecular Life Sciences, Cluster of Excellence "Macromolecular Complexes," Goethe University Frankfurt, Frankfurt am Main, Germany.
Nat Chem Biol ; 13(4): 363-365, 2017 04.
Article em En | MEDLINE | ID: mdl-28218912
ABSTRACT
In this study, we engineered fatty acid synthases (FAS) for the biosynthesis of short-chain fatty acids and polyketides, guided by a combined in vitro and in silico approach. Along with exploring the synthetic capability of FAS, we aim to build a foundation for efficient protein engineering, with the specific goal of harnessing evolutionarily related megadalton-scale polyketide synthases (PKS) for the tailored production of bioactive natural compounds.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Engenharia de Proteínas / Ácido Graxo Sintases / Policetídeos Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Engenharia de Proteínas / Ácido Graxo Sintases / Policetídeos Idioma: En Ano de publicação: 2017 Tipo de documento: Article