Development of drug delivery systems for taxanes using ionic gelation of carboxyacyl derivatives of chitosan.
Carbohydr Polym
; 162: 49-55, 2017 Apr 15.
Article
em En
| MEDLINE
| ID: mdl-28224894
ABSTRACT
Nanoparticles of two chitosan derivatives - N-succinyl-chitosan (SC) and N-glutaryl-chitosan (GC) - were developed as passive transport systems for taxanes (paclitaxel and docetaxel) using an ionic gelation technique with sodium tripolyphosphate. These nanoparticles had an apparent hydrodynamic diameter of 300-350nm, a ζ-potential of 25-31mV, an encapsulation efficiency of 21-26%, and a drug loading efficiency of 6-13%. DLS and SLS analysis shows that the nanoparticles have a unimodal size distribution and spherical form. Drug release kinetics of the taxane-loaded nanoparticles demonstrates that more than 50% of the loaded taxane could be released upon the degradation of the nanoparticles after targeted delivery. The drug-loaded SC and GC nanoparticles exhibit high cytotoxicity towards AGS cancer cell lines and their antitumor activity is consequently enhanced when compared with free taxanes.
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Base de dados:
MEDLINE
Assunto principal:
Sistemas de Liberação de Medicamentos
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Taxoides
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Quitosana
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article