Three Chalconoids and a Pterocarpene from the Roots of Tephrosia aequilata.
Molecules
; 22(2)2017 Feb 20.
Article
em En
| MEDLINE
| ID: mdl-28230755
ABSTRACT
In our search for new antiplasmodial agents, the CH2Cl2/CH3OH (11) extract of the roots of Tephrosia aequilata was investigated, and observed to cause 100% mortality of the chloroquine-sensitive (3D7) strain of Plasmodium falciparum at a 10 mg/mL concentration. From this extract three new chalconoids, E-2',6'-dimethoxy-3',4'-(2'',2''-dimethyl)pyranoretrochalcone (1, aequichalcone A), Z-2',6'-dimethoxy-3',4'-(2'',2''-dimethyl)pyranoretrochalcone (2, aequichalcone B), 4''-ethoxy-3''-hydroxypraecansone B (3, aequichalcone C) and a new pterocarpene, 3,48,9-dimethylenedioxy-6a,11a-pterocarpene (4), along with seven known compounds were isolated. The purified compounds were characterized by NMR spectroscopic and mass spectrometric analyses. Compound 1 slowly converts into 2 in solution, and thus the latter may have been enriched, or formed, during the extraction and separation process. The isomeric compounds 1 and 2 were both observed in the crude extract. Some of the isolated constituents showed good to moderate antiplasmodial activity against the chloroquine-sensitive (3D7) strain of Plasmodium falciparum.
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Base de dados:
MEDLINE
Assunto principal:
Extratos Vegetais
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Raízes de Plantas
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Tephrosia
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Pterocarpanos
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Chalconas
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article