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Resident macrophages in the healthy and inflamed intestinal muscularis externa.
Wehner, Sven; Engel, Daniel Robert.
Afiliação
  • Wehner S; Department of Surgery/Immune Pathophysiology, University of Bonn, 53121, Bonn, Germany. sven.wehner@ukbonn.de.
  • Engel DR; Institute for Experimental Immunology and Imaging, Department of Immunodynamics, University Duisburg-Essen and University Hospital Essen, 45147, Essen, Germany. engel@immunodynamics.de.
Pflugers Arch ; 469(3-4): 541-552, 2017 04.
Article em En | MEDLINE | ID: mdl-28236119
Macrophages reside in a dense cellular network in the intestinal muscularis externa, and there is emerging evidence that the functionality of these cells determines the local microenvironment. Inflammatory responses during intestinal diseases change the homeostatic functionality of these cells causing inflammation and intestinal dysmotility. Such disturbances are not only induced by a change in the cellular composition in the intestinal muscularis but also by an altered crosstalk with the peripheral and central nervous system. In this review, we summarize the role of muscularis macrophages in the intestine in homeostasis and inflammation. We compare the functionality, the phenotype, and the origin of muscularis macrophages to their neighboring counterparts within the different layers of the intestine. We outline the cellular crosstalk with the enteric and the peripheral nervous system and summarize the current therapeutic approaches to modulate the functionality of these phagocytes.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Inflamação / Intestinos / Macrófagos Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Inflamação / Intestinos / Macrófagos Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article