Effects of Therapeutic Hypothermia for Neuroprotection from the Viewpoint of Redox Regulation.
Acta Med Okayama
; 71(1): 1-9, 2017 Feb.
Article
em En
| MEDLINE
| ID: mdl-28238004
ABSTRACT
Redox regulation has recently been recognized as an important factor in acute illnesses as well as in chronic diseases. It has also become a target for neuroprotection in acute intensive care. Despite its well-known therapeutic effects, therapeutic hypothermia has recently been re-evaluated for its potential use in emergency and critical care medicine. Hypothermia is an undesirable physiological condition that can increase oxidative stress and decrease anti-oxidative potency. However, many studies have shown that under ischemia/reperfusion conditions, therapeutic hypothermia actually suppresses enhanced oxidative stress and maintains or increases anti-oxidative potency. This review provides an overview and outlook for the future of therapeutic hypothermia for neuroprotection from the perspective of redox regulation in patients with post-cardiac arrest syndrome and traumatic brain injury.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Estresse Oxidativo
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Cuidados Críticos
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Neuroproteção
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Hipotermia Induzida
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article