Consensus-based recommendations for the management of rapid cognitive decline due to Alzheimer's disease.
Alzheimers Dement
; 13(5): 592-597, 2017 May.
Article
em En
| MEDLINE
| ID: mdl-28238739
ABSTRACT
INTRODUCTION:
Rapid cognitive decline (RCD) occurs in dementia due to Alzheimer's disease (AD).METHODS:
Literature review, consensus meetings, and a retrospective chart review of patients with probable AD were conducted.RESULTS:
Literature review showed that RCD definitions varied. Mini-Mental State Examination scores <20 at treatment onset, vascular risk factors, age <70 years at symptom onset, higher education levels, and early appearance of hallucinations, psychosis, or extrapyramidal symptoms are recognized RCD risk factors. Chart review showed that RCD (Mini-Mental State Examination score decline ≥3 points/year) is more common in moderate (43.2%) than in mild patients (20.1%; P < .001). Rapid and slow decliners had similar age, gender, and education levels at baseline.DISCUSSION:
RCD is sufficiently common to interfere with randomized clinical trials. We propose a 6-month prerandomization determination of the decline rate or use of an RCD risk score to ensure balanced allocation among treatment groups.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Progressão da Doença
/
Doença de Alzheimer
/
Disfunção Cognitiva
Tipo de estudo:
Clinical_trials
/
Diagnostic_studies
/
Guideline
/
Risk_factors_studies
Limite:
Female
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article