The Indirubin Derivative 6-Bromoindirubin-3'-Oxime Activates Proteostatic Modules, Reprograms Cellular Bioenergetic Pathways, and Exerts Antiaging Effects.

Tsakiri, Eleni N; Gaboriaud-Kolar, Nicolas; Iliaki, Kalliopi K; Tchoumtchoua, Job; Papanagnou, Eleni-Dimitra; Chatzigeorgiou, Sofia; Tallas, Konstantinos D; Mikros, Emmanuel; Halabalaki, Maria; Skaltsounis, Alexios-Leandros; Trougakos, Ioannis P

Tsakiri, Eleni N; Gaboriaud-Kolar, Nicolas; Iliaki, Kalliopi K; Tchoumtchoua, Job; Papanagnou, Eleni-Dimitra; Chatzigeorgiou, Sofia; Tallas, Konstantinos D; Mikros, Emmanuel; Halabalaki, Maria; Skaltsounis, Alexios-Leandros; Trougakos, Ioannis P.

Afiliação

Tsakiri EN; 1 Department of Cell Biology and Biophysics, Faculty of Biology, National and Kapodistrian University of Athens , Athens, Greece .
Gaboriaud-Kolar N; 2 Department of Pharmacognosy and Natural Products Chemistry, Faculty of Pharmacy, National and Kapodistrian University of Athens , Athens, Greece .
Iliaki KK; 1 Department of Cell Biology and Biophysics, Faculty of Biology, National and Kapodistrian University of Athens , Athens, Greece .
Tchoumtchoua J; 2 Department of Pharmacognosy and Natural Products Chemistry, Faculty of Pharmacy, National and Kapodistrian University of Athens , Athens, Greece .
Papanagnou ED; 1 Department of Cell Biology and Biophysics, Faculty of Biology, National and Kapodistrian University of Athens , Athens, Greece .
Chatzigeorgiou S; 1 Department of Cell Biology and Biophysics, Faculty of Biology, National and Kapodistrian University of Athens , Athens, Greece .
Tallas KD; 1 Department of Cell Biology and Biophysics, Faculty of Biology, National and Kapodistrian University of Athens , Athens, Greece .
Mikros E; 3 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, National and Kapodistrian University of Athens , Athens, Greece .
Halabalaki M; 2 Department of Pharmacognosy and Natural Products Chemistry, Faculty of Pharmacy, National and Kapodistrian University of Athens , Athens, Greece .
Skaltsounis AL; 2 Department of Pharmacognosy and Natural Products Chemistry, Faculty of Pharmacy, National and Kapodistrian University of Athens , Athens, Greece .
Trougakos IP; 1 Department of Cell Biology and Biophysics, Faculty of Biology, National and Kapodistrian University of Athens , Athens, Greece .

Antioxid Redox Signal ; 27(14): 1027-1047, 2017 Nov 10.

Article em En | MEDLINE | ID: mdl-28253732

Assuntos

Envelhecimento/efeitos dos fármacos; Drosophila melanogaster/efeitos dos fármacos; Metabolismo Energético/efeitos dos fármacos; Indóis/administração & dosagem; Oximas/administração & dosagem; Proteostase/efeitos dos fármacos; Administração Oral; Envelhecimento/metabolismo; Animais; Modelos Animais de Doenças; Proteínas de Drosophila/metabolismo; Drosophila melanogaster/metabolismo; Feminino; Quinase 3 da Glicogênio Sintase/metabolismo; Humanos; Indóis/farmacologia; Masculino; Redes e Vias Metabólicas/efeitos dos fármacos; Fator 2 Relacionado a NF-E2/metabolismo; Oximas/farmacologia

Palavras-chave

6-bromoindirubin-3'-oxime; Gsk-3; Nrf-2; Pdpk1; aging; proteostasis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oximas / Envelhecimento / Drosophila melanogaster / Metabolismo Energético / Proteostase / Indóis Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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