1-ethyl-3-(6-methylphenanthridine-8-il) urea modulates TLR3/9 activation and induces selective pro-inflammatory cytokine expression in vitro.
Bioorg Med Chem Lett
; 27(7): 1530-1537, 2017 04 01.
Article
em En
| MEDLINE
| ID: mdl-28254484
ABSTRACT
We have previously demonstrated the nucleic acid binding capacity of phenanthridine derivatives (PHTs). Because nucleic acids are potent inducers of innate immune response through Toll-like receptors (TLRs), and because PTHs bear a structural resemblance to commonly used synthetic ligands for TLR7/8, we hypothesized that PHTs could modulate/activate immune response. We found that compound M199 induces secretion of IL-6, IL-8 and TNFα in human PBMCs and inhibits TLR3/9 activation in different cellular systems (PBMCs, HEK293 and THP-1 cell lines).
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fenantridinas
/
Ureia
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Receptor Toll-Like 9
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Receptor 3 Toll-Like
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Fatores Imunológicos
Limite:
Humans
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article