ceRNA crosstalk stabilizes protein expression and affects the correlation pattern of interacting proteins.
Sci Rep
; 7: 43673, 2017 03 07.
Article
em En
| MEDLINE
| ID: mdl-28266541
ABSTRACT
Gene expression is a noisy process and several mechanisms, both transcriptional and post-transcriptional, can stabilize protein levels in cells. Much work has focused on the role of miRNAs, showing in particular that miRNA-mediated regulation can buffer expression noise for lowly expressed genes. Here, using in silico simulations and mathematical modeling, we demonstrate that miRNAs can exert a much broader influence on protein levels by orchestrating competition-induced crosstalk between mRNAs. Most notably, we find that miRNA-mediated cross-talk (i) can stabilize protein levels across the full range of gene expression rates, and (ii) modifies the correlation pattern of co-regulated interacting proteins, changing the sign of correlations from negative to positive. The latter feature may constitute a potentially robust signature of the existence of RNA crosstalk induced by endogenous competition for miRNAs in standard cellular conditions.
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Base de dados:
MEDLINE
Assunto principal:
RNA
/
Proteínas de Transporte
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Regulação da Expressão Gênica
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Interferência de RNA
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Epistasia Genética
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article