Development and validation of an HPLC-UV method for the simultaneous determination of the antipsychotics clozapine, olanzapine and quetiapine, several beta-blockers and their metabolites.

Silva Gracia, Margarete; Köppl, Alexandra; Unholzer, Sandra; Haen, Ekkehard

Silva Gracia, Margarete; Köppl, Alexandra; Unholzer, Sandra; Haen, Ekkehard.

Afiliação

Silva Gracia M; Clinical Pharmacology, Department of Psychiatry and Psychotherapy and Department of Pharmacology and Toxicology, University of Regensburg, Regensburg, Germany.
Köppl A; Clinical Pharmacology, Department of Psychiatry and Psychotherapy and Department of Pharmacology and Toxicology, University of Regensburg, Regensburg, Germany.
Unholzer S; Clinical Pharmacology, Department of Psychiatry and Psychotherapy and Department of Pharmacology and Toxicology, University of Regensburg, Regensburg, Germany.
Haen E; Clinical Pharmacology, Department of Psychiatry and Psychotherapy and Department of Pharmacology and Toxicology, University of Regensburg, Regensburg, Germany.

Biomed Chromatogr ; 31(10)2017 Oct.

Article em En | MEDLINE | ID: mdl-28266722

Assuntos

Antagonistas Adrenérgicos beta/sangue; Antipsicóticos/sangue; Benzodiazepinas/sangue; Cromatografia Líquida de Alta Pressão/métodos; Fumarato de Quetiapina/sangue; Antagonistas Adrenérgicos beta/química; Antipsicóticos/química; Benzodiazepinas/química; Humanos; Limite de Detecção; Modelos Lineares; Fumarato de Quetiapina/química; Reprodutibilidade dos Testes

Palavras-chave

HPLC; antipsychotics; beta-blockers; column-switching; therapeutic drug monitoring

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antipsicóticos / Benzodiazepinas / Cromatografia Líquida de Alta Pressão / Antagonistas Adrenérgicos beta / Fumarato de Quetiapina Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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