Analysis of the skin of mice humanized for the immune system.
Exp Dermatol
; 26(10): 963-966, 2017 10.
Article
em En
| MEDLINE
| ID: mdl-28267869
ABSTRACT
Development of new immunotherapeutic strategies relies on the ability to activate the right cells at the right place and at the right moment and on the capacity of these cells to home to the right organ(s). Skin delivery has shown high potency for immunotherapeutic administration. However, an adequate in vivo model of human skin immunity is still a critical bottleneck. We demonstrated here that the skin of human immune system mice is colonized by human hematopoietic cells, mainly human T cells and that complementation with human antigen-presenting cells at the vaccination site allowed the induction of an immune response.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pele
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Células-Tronco Hematopoéticas
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Antígeno HLA-A2
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Modelos Animais
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article