Pertussis toxin blocks a late inhibitory postsynaptic potential in hippocampal CA3 neurons.
Neurosci Lett
; 82(1): 41-6, 1987 Nov 10.
Article
em En
| MEDLINE
| ID: mdl-2827070
ABSTRACT
These experiments show that a synaptic response, namely the late inhibitory postsynaptic potential (IPSP) of hippocampal CA3 neurons of rats, is blocked by pertussis toxin, an inactivator of several GTP-binding proteins (G-proteins) excluding the G-protein that stimulates adenylyl cyclase. This blockage occurred without a similar effect upon either the mossy fiber-evoked EPSP or the early (GABAa-mediated) IPSP. The toxin also blocked the response to baclofen, an agonist for a putative receptor (GABAb) mediating the late IPSP, but did not affect the response to THIP, an agonist for the receptor (GABAa) mediating the early IPSP. It is proposed that a pertussis toxin-sensitive G-protein controls the conductance of the late IPSP.
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Base de dados:
MEDLINE
Assunto principal:
Fatores de Virulência de Bordetella
/
Toxina Adenilato Ciclase
/
Toxina Pertussis
/
Hipocampo
/
Inibição Neural
Limite:
Animals
Idioma:
En
Ano de publicação:
1987
Tipo de documento:
Article