Synthesis of Cyclic α-Diazo-ß-keto Sulfoxides in Batch and Continuous Flow.
J Org Chem
; 82(7): 3666-3679, 2017 04 07.
Article
em En
| MEDLINE
| ID: mdl-28272889
ABSTRACT
Diazo transfer to ß-keto sulfoxides to form stable isolable α-diazo-ß-keto sulfoxides has been achieved for the first time. Both monocyclic and benzofused ketone derived ß-keto sulfoxides were successfully explored as substrates for diazo transfer. Use of continuous flow leads to isolation of the desired compounds in enhanced yields relative to standard batch conditions, with short reaction times, increased safety profile, and potential to scale up.
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MEDLINE
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En
Ano de publicação:
2017
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Article