Gentamicin B1 is a minor gentamicin component with major nonsense mutation suppression activity.

Baradaran-Heravi, Alireza; Niesser, Jürgen; Balgi, Aruna D; Choi, Kunho; Zimmerman, Carla; South, Andrew P; Anderson, Hilary J; Strynadka, Natalie C; Bally, Marcel B; Roberge, Michel

Baradaran-Heravi, Alireza; Niesser, Jürgen; Balgi, Aruna D; Choi, Kunho; Zimmerman, Carla; South, Andrew P; Anderson, Hilary J; Strynadka, Natalie C; Bally, Marcel B; Roberge, Michel.

Afiliação

Baradaran-Heravi A; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada V6T 1Z3.
Niesser J; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada V6T 1Z3.
Balgi AD; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada V6T 1Z3.
Choi K; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada V6T 1Z3.
Zimmerman C; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada V6T 1Z3.
South AP; Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, PA 19107.
Anderson HJ; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada V6T 1Z3.
Strynadka NC; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada V6T 1Z3.
Bally MB; Department of Experimental Therapeutics, British Columbia Cancer Agency, Vancouver, BC, Canada V5Z 1L3.
Roberge M; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada V6T 1Z3; michelr@mail.ubc.ca.

Proc Natl Acad Sci U S A ; 114(13): 3479-3484, 2017 03 28.

Article em En | MEDLINE | ID: mdl-28289221

Assuntos

Antibacterianos/farmacologia; Códon sem Sentido/genética; Gentamicinas/farmacologia; Mutação/efeitos dos fármacos; Aminopeptidases/genética; Antibacterianos/química; Linhagem Celular Tumoral; Dipeptidil Peptidases e Tripeptidil Peptidases/genética; Distrofina/genética; Gentamicinas/química; Humanos; Serina Proteases/genética; Tripeptidil-Peptidase 1; Proteína Supressora de Tumor p53/genética

Palavras-chave

cancer; gentamicin B1; nonsense mutation; premature stop codon readthrough; rare genetic diseases

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Gentamicinas / Códon sem Sentido / Antibacterianos / Mutação Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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