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Biseokeaniamides A, B, and C, Sterol O-Acyltransferase Inhibitors from an Okeania sp. Marine Cyanobacterium.
Iwasaki, Arihiro; Tadenuma, Takato; Sumimoto, Shimpei; Ohshiro, Taichi; Ozaki, Kaori; Kobayashi, Keisuke; Teruya, Toshiaki; Tomoda, Hiroshi; Suenaga, Kiyotake.
Afiliação
  • Iwasaki A; Department of Chemistry, Faculty of Science and Technology, Keio University , 3-14-1 Hiyoshi, Kohoku-ku, Yokohama, Kanagawa 223-8522, Japan.
  • Tadenuma T; Department of Chemistry, Faculty of Science and Technology, Keio University , 3-14-1 Hiyoshi, Kohoku-ku, Yokohama, Kanagawa 223-8522, Japan.
  • Sumimoto S; Department of Chemistry, Faculty of Science and Technology, Keio University , 3-14-1 Hiyoshi, Kohoku-ku, Yokohama, Kanagawa 223-8522, Japan.
  • Ohshiro T; Graduate School of Pharmaceutical Sciences, Kitasato University , 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan.
  • Ozaki K; Faculty of Education, University of the Ryukyus , 1 Senbaru, Nishihara, Okinawa 903-0213, Japan.
  • Kobayashi K; Graduate School of Pharmaceutical Sciences, Kitasato University , 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan.
  • Teruya T; Faculty of Education, University of the Ryukyus , 1 Senbaru, Nishihara, Okinawa 903-0213, Japan.
  • Tomoda H; Graduate School of Pharmaceutical Sciences, Kitasato University , 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan.
  • Suenaga K; Department of Chemistry, Faculty of Science and Technology, Keio University , 3-14-1 Hiyoshi, Kohoku-ku, Yokohama, Kanagawa 223-8522, Japan.
J Nat Prod ; 80(4): 1161-1166, 2017 04 28.
Article em En | MEDLINE | ID: mdl-28294609
ABSTRACT
Biseokeaniamides A, B, and C (1-3), structurally novel sterol O-acyltransferase (SOAT) inhibitors, were isolated from an Okeania sp. marine cyanobacterium. Their structures were elucidated by spectroscopic analyses and degradation reactions. Biseokeaniamide B (2) exhibited moderate cytotoxicity against human HeLa cancer cells, and compounds 1-3 inhibited both SOAT1 and SOAT2, not only at an enzyme level but also at a cellular level. Biseokeaniamides (1-3) are the first linear lipopeptides that have been shown to exhibit SOAT-inhibitory activity.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Esterol O-Aciltransferase / Cianobactérias / Lipopeptídeos / Antineoplásicos Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Esterol O-Aciltransferase / Cianobactérias / Lipopeptídeos / Antineoplásicos Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article