[The expression of claudins in colonic neoplasms]. / Osobennosti ekspressii klaudinov v novoobrazovaniyakh tolstoi kishki.
Arkh Patol
; 79(1): 28-35, 2017.
Article
em Ru
| MEDLINE
| ID: mdl-28295005
ABSTRACT
AIM:
the evaluation of localization claudin-1, -3 and -4 types of cancer and colon polyps. MATERIAL ANDMETHODS:
The study included 32 colon adenocarcinoma and 86 polyps. Antibody claudin-1; -3 and -4 were used as immunohistochemical markers in this study.RESULTS:
84/118, 64/118, 52/118 reaction with claudin-1, claudin-3 and claudin-4 in cancer and colon polyps had a membrane localization, respectively. In 33 (27.9%) cases was found paradoxical reaction claudin-1; in 50 (42.4%) - a paradoxical reaction claudin-3 in 66 (55.9%) - a paradoxical reaction claudin-4. Among the paradoxical claudin reaction nuclear localization of marker was observed relatively rarely claudin-3 in 2.5% cases of colon cancer; claudin-4 in 8.5% of colon polyps.CONCLUSION:
Mislocalization claudin-3 to nucleus in colon cancer and mislocalization claudin-4 to nucleus in adenomas of the colon were detected for the first time. The potential reasons for the paradoxical expression are discussed and a review of the literature, related all the alleged mechanisms of this mislocalization is provided.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Adenocarcinoma
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Adenoma
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Neoplasias do Colo
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Claudina-1
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Claudina-3
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Claudina-4
Limite:
Adult
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Aged
/
Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
Ru
Ano de publicação:
2017
Tipo de documento:
Article