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Blunted beta-adrenergic responsivity of peripheral blood mononuclear cells in endogenous depression. Isoproterenol dose-response studies.
Halper, J P; Brown, R P; Sweeney, J A; Kocsis, J H; Peters, A; Mann, J J.
Afiliação
  • Halper JP; Department of Psychiatry, Cornell University Medical College, New York, NY 10021.
Arch Gen Psychiatry ; 45(3): 241-4, 1988 Mar.
Article em En | MEDLINE | ID: mdl-2829786
Previous studies of peripheral blood mononuclear cells isolated from drug-free, hospitalized patients with endogenous major depression have demonstrated a diminished adenosine 3',5'-monophosphate (cyclic AMP) response to single concentrations of isoproterenol as compared with that obtained from normal control subjects. We now report results of isoproterenol dose-response studies that indicate lower basal levels of cyclic AMP as well as diminished cyclic AMP levels in response to isoproterenol stimulation at concentrations ranging from 10(-10) to 10(-5) mol/L in drug-free, hospitalized patients with endogenous depression. The major factor responsible for the diminished cyclic AMP production in the depressed patients was a loss of receptor sites capable of cyclic AMP production. Taken together with our previously reported finding that beta-adrenergic antagonist binding was normal in peripheral blood mononuclear cells obtained from depressed patients, the results of the dose-response studies suggest a loss of receptor function (desensitization) rather than a diminished number of receptor binding sites (down-regulation) as the underlying mechanism. Potential explanations for beta-adrenergic desensitization and its implications for the catecholamine hypothesis of depressive disorders are discussed.
Assuntos
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Base de dados: MEDLINE Assunto principal: Leucócitos Mononucleares / Receptores Adrenérgicos beta / Transtorno Depressivo / Isoproterenol Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 1988 Tipo de documento: Article
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Base de dados: MEDLINE Assunto principal: Leucócitos Mononucleares / Receptores Adrenérgicos beta / Transtorno Depressivo / Isoproterenol Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 1988 Tipo de documento: Article