Inhibition of Calcineurin A by FK506 Suppresses Seizures and Reduces the Expression of GluN2B in Membrane Fraction.

Wen, Yuetao; Fu, Pengfei; Wu, Kunlun; Si, Kaichuang; Xie, Yanfeng; Dan, Wei; Zhan, Yan; Shi, Quanhong

Wen, Yuetao; Fu, Pengfei; Wu, Kunlun; Si, Kaichuang; Xie, Yanfeng; Dan, Wei; Zhan, Yan; Shi, Quanhong.

Afiliação

Wen Y; Department of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, No.1, Youyi Road, Chongqing, 400010, China.
Fu P; Department of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, No.1, Youyi Road, Chongqing, 400010, China.
Wu K; Department of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, No.1, Youyi Road, Chongqing, 400010, China.
Si K; Department of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, No.1, Youyi Road, Chongqing, 400010, China.
Xie Y; Department of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, No.1, Youyi Road, Chongqing, 400010, China.
Dan W; Department of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, No.1, Youyi Road, Chongqing, 400010, China.
Zhan Y; Department of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, No.1, Youyi Road, Chongqing, 400010, China.
Shi Q; Department of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, No.1, Youyi Road, Chongqing, 400010, China. 417149803@qq.com.

Neurochem Res ; 42(8): 2154-2166, 2017 Aug.

Article em En | MEDLINE | ID: mdl-28299629

Assuntos

Inibidores de Calcineurina/uso terapêutico; Membrana Celular/metabolismo; Receptores de N-Metil-D-Aspartato/antagonistas & inibidores; Receptores de N-Metil-D-Aspartato/biossíntese; Convulsões/metabolismo; Tacrolimo/uso terapêutico; Adolescente; Adulto; Animais; Calcineurina/metabolismo; Inibidores de Calcineurina/farmacologia; Membrana Celular/efeitos dos fármacos; Membrana Celular/genética; Pré-Escolar; Epilepsia do Lobo Temporal/tratamento farmacológico; Epilepsia do Lobo Temporal/genética; Epilepsia do Lobo Temporal/metabolismo; Feminino; Expressão Gênica; Humanos; Masculino; Pessoa de Meia-Idade; Distribuição Aleatória; Ratos; Ratos Sprague-Dawley; Receptores de N-Metil-D-Aspartato/genética; Convulsões/tratamento farmacológico; Convulsões/genética; Tacrolimo/farmacologia; Adulto Jovem

Palavras-chave

Calcineurin A; Internalization; N-methyl-D-aspartate receptor 2B; Phosphorylation; Temporal lobe epilepsy

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Convulsões / Membrana Celular / Tacrolimo / Receptores de N-Metil-D-Aspartato / Inibidores de Calcineurina Tipo de estudo: Clinical_trials Limite: Adolescent / Adult / Animals / Child, preschool / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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