Polyamidoamine dendrimer-conjugated triamcinolone acetonide attenuates nerve injury-induced spinal cord microglia activation and mechanical allodynia.

Kim, Hwisung; Choi, Boomin; Lim, Hyoungsub; Min, Hyunjung; Oh, Jae Hoon; Choi, Sunghyun; Cho, Joung Goo; Park, Jong-Sang; Lee, Sung Joong

Kim, Hwisung; Choi, Boomin; Lim, Hyoungsub; Min, Hyunjung; Oh, Jae Hoon; Choi, Sunghyun; Cho, Joung Goo; Park, Jong-Sang; Lee, Sung Joong.

Afiliação

Kim H; 1 Department of Neuroscience and Physiology, Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Republic of Korea.
Choi B; 1 Department of Neuroscience and Physiology, Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Republic of Korea.
Lim H; 1 Department of Neuroscience and Physiology, Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Republic of Korea.
Min H; 1 Department of Neuroscience and Physiology, Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Republic of Korea.
Oh JH; 2 School of Chemistry and Molecular Engineering, Seoul National University, Seoul, Republic of Korea.
Choi S; 2 School of Chemistry and Molecular Engineering, Seoul National University, Seoul, Republic of Korea.
Cho JG; 3 Department of Anesthesiology and Pain Medicine, National Health Insurance Service Ilsan Hospital, Ilsan, Republic of Korea.
Park JS; 2 School of Chemistry and Molecular Engineering, Seoul National University, Seoul, Republic of Korea.
Lee SJ; 1 Department of Neuroscience and Physiology, Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Republic of Korea.

Mol Pain ; 13: 1744806917697006, 2017 01.

Article em En | MEDLINE | ID: mdl-28326946

Assuntos

Hiperalgesia/etiologia; Microglia/efeitos dos fármacos; Traumatismos dos Nervos Periféricos/complicações; Medula Espinal/patologia; Triancinolona Acetonida/farmacologia; Animais; Anti-Inflamatórios/farmacologia; Anti-Inflamatórios/uso terapêutico; Proteínas de Ligação ao Cálcio/metabolismo; Células Cultivadas; Citocinas/metabolismo; Dendrímeros/química; Dendrímeros/uso terapêutico; Modelos Animais de Doenças; Relação Dose-Resposta a Droga; Proteína Glial Fibrilar Ácida/metabolismo; Masculino; Glicoproteínas de Membrana/metabolismo; Camundongos; Camundongos Endogâmicos C57BL; Proteínas dos Microfilamentos/metabolismo; NADPH Oxidase 2; NADPH Oxidases/metabolismo; Traumatismos dos Nervos Periféricos/patologia; Triancinolona Acetonida/química; Triancinolona Acetonida/uso terapêutico

Palavras-chave

Dendrimer-triamcinolone acetonide; neuropathic pain; peripheral nerve injury; spinal cord microglia

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Medula Espinal / Triancinolona Acetonida / Microglia / Traumatismos dos Nervos Periféricos / Hiperalgesia Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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