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Randomised controlled trial demonstrates that fermented infant formula with short-chain galacto-oligosaccharides and long-chain fructo-oligosaccharides reduces the incidence of infantile colic.
Vandenplas, Yvan; Ludwig, Thomas; Bouritius, Hetty; Alliet, Philippe; Forde, Derek; Peeters, Stefaan; Huet, Frederic; Hourihane, Jonathan.
Afiliação
  • Vandenplas Y; Department of Pediatrics, UZ, Vrije Universiteit Brussel, Brussels, Belgium.
  • Ludwig T; Nutricia Research, Utrecht, The Netherlands.
  • Bouritius H; Nutricia Research, Utrecht, The Netherlands.
  • Alliet P; Kinderartsenpraktijk, Hasselt, Belgium.
  • Forde D; Slaney Medical Centre, Enniscorthy, Ireland.
  • Peeters S; Algemeen Stedelijk Ziekenhuis Aalst, Aalst, Belgium.
  • Huet F; Pédiatrie, Hôpital d'Enfants, Dijon, France.
  • Hourihane J; Paediatrics and Child Health, University College Cork, Cork, Ireland.
Acta Paediatr ; 106(7): 1150-1158, 2017 Jul.
Article em En | MEDLINE | ID: mdl-28328065
AIM: We examined the effects on gastrointestinal (GI) tolerance of a novel infant formula that combined specific fermented formula (FERM) with short-chain galacto-oligosaccharides and long-chain fructo-oligosaccharides (scGOS/lcFOS), with a 9:1 ratio and concentration of 0.8 g/100 mL. METHODS: This prospective, double-blind, randomised, controlled trial comprised 432 healthy, term infants aged 0-28 days whose parents decided to not start, or discontinued, breastfeeding. Infant formula with scGOS/lcFOS+50%FERM, scGOS/lcFOS+15%FERM, 50%FERM and scGOS/lcFOS were tested. Parents completed standardised seven-day diaries on GI symptoms, crying, sleeping and stool characteristics each month until the infants were 17 weeks. RESULTS: All the formulas were well tolerated. At four weeks, the overall incidence of infantile colic was significantly lower (8%) with scGOS/lcFOS+50%FERM than scGOS/lcFOS (20%, p = 0.034) or 50%FERM (20%, p = 0.036). Longitudinal modelling showed that scGOS/lcFOS+50%FERM-fed infants also displayed a persistently lower daily crying duration and showed a consistent stool-softening effect than infants who received formula without scGOS/lcFOS. CONCLUSION: The combination of fermented formula with scGOS/lcFOS was well tolerated and showed a lower overall crying time, a lower incidence of infantile colic and a stool-softening effect in healthy term infants. These findings suggest for the first time that a specific infant formula has a preventive effect on infantile colic in formula-fed infants.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oligossacarídeos / Cólica / Produtos Fermentados do Leite / Fórmulas Infantis / Prebióticos Tipo de estudo: Clinical_trials / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans / Infant / Newborn Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oligossacarídeos / Cólica / Produtos Fermentados do Leite / Fórmulas Infantis / Prebióticos Tipo de estudo: Clinical_trials / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans / Infant / Newborn Idioma: En Ano de publicação: 2017 Tipo de documento: Article