5-Fluorouracil-induced exacerbation of rosacea.
Dermatol Online J
; 22(11)2016 Nov 15.
Article
em En
| MEDLINE
| ID: mdl-28329576
ABSTRACT
Background Topical 5-fluorouracil (5-FU) is an antineoplastic antimetabolite used for the treatment of actinic keratosis.Purpose A 66-year-old man with erythematotelangiectatic rosacea and biopsy-confirmed actinic keratoses who experienced a rosacea exacerbation after initiating topical 5-FU treatment of his actinic keratoses is described and this adverse event associated with 5-FU is reviewed.Materials and methods Using PubMed.gov the following terms were searched and relevant citations were assessed rosacea and 5-fluorouracil. 5-FU drug label information and data sheets also were reviewed.ResultsErythematous facial papules developed within a week of starting topical treatment of his actinic keratoses with 5-FU. The lesions resolved within two weeks of discontinuing the medication. Albeit rarely, exacerbation of rosacea by topical 5-FU treatment has been described when 5-FU was introduced as a topical treatment for actinic keratosis.Conclusion Topical 5-FU has been associated with several adverse cutaneous events, including accentuation of rosacea. Although rosacea flares due to topical 5-FU may be uncommon, the incidence may be greater than reflected in the literature. Physicians should be aware of this potential adverse effect in patients in whom they plan to initiate 5-FU therapy.
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Base de dados:
MEDLINE
Assunto principal:
Rosácea
/
Ceratose Actínica
/
Fluoruracila
/
Antineoplásicos
Limite:
Aged
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article