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Three-dimensional oxygen-enhanced MRI of the human lung at 1.5T with ultra-fast balanced steady-state free precession.
Pusterla, Orso; Bauman, Grzegorz; Bieri, Oliver.
Afiliação
  • Pusterla O; Division of Radiological Physics, Department of Radiology, University of Basel Hospital, Basel, Switzerland.
  • Bauman G; Department of Biomedical Engineering, University of Basel, Basel, Switzerland.
  • Bieri O; Division of Radiological Physics, Department of Radiology, University of Basel Hospital, Basel, Switzerland.
Magn Reson Med ; 79(1): 246-255, 2018 Jan.
Article em En | MEDLINE | ID: mdl-28337782
ABSTRACT

PURPOSE:

To assess the feasibility of 3D oxygen-enhanced (OE) MRI of the lung at 1.5T using multi-volumetric ultra-fast balanced steady-state free precession (ufSSFP) acquisitions.

METHODS:

Isotropic imaging of the lung for OE-MRI was performed with an adapted 3D ufSSFP sequence using five breath-hold acquisitions ranging from functional residual capacity to tidal inspiration under both normoxic (room air) and hyperoxic (100% O2 ) gas conditions. For each O2 concentration, a sponge model (which captures the parenchymal signal intensity variation as a function of the lung volume) was fitted to the acquired multi-volumetric datasets after semiautomatic lung segmentation and deformable image registration. From the retrieved model parameters, 3D oxygen-enhancement maps were calculated.

RESULTS:

For OE ufSSFP imaging, the maximum parenchymal signal is observed for flip angles around 23° under both normoxic and hyperoxic conditions. It is found that the sponge model accurately describes parenchymal signal at different breathing positions, thereby mitigating the confounding bias in the estimated oxygen enhancement from residual density modulations. From the model, an average lung oxygen enhancement of 7.0% ± 0.3% was found in the healthy volunteers, and the oxygen-enhancement maps indicate a ventral to dorsal gravitation-related gradient.

CONCLUSION:

The study demonstrates the feasibility of whole-lung OE-MRI from multi-volumetric ufSSFP in healthy volunteers. Magn Reson Med 79246-255, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oxigênio / Processamento de Imagem Assistida por Computador / Imageamento por Ressonância Magnética / Imageamento Tridimensional / Pulmão Tipo de estudo: Prognostic_studies Limite: Adult / Female / Humans / Male Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oxigênio / Processamento de Imagem Assistida por Computador / Imageamento por Ressonância Magnética / Imageamento Tridimensional / Pulmão Tipo de estudo: Prognostic_studies Limite: Adult / Female / Humans / Male Idioma: En Ano de publicação: 2018 Tipo de documento: Article