The Upsides and Downsides of Organelle Interconnectivity.
Cell
; 169(1): 24-34, 2017 03 23.
Article
em En
| MEDLINE
| ID: mdl-28340346
ABSTRACT
Interconnectivity and feedback control are hallmarks of biological systems. This includes communication between organelles, which allows them to function and adapt to changing cellular environments. While the specific mechanisms for all communications remain opaque, unraveling the wiring of organelle networks is critical to understand how biological systems are built and why they might collapse, as occurs in aging. A comprehensive understanding of all the routes involved in inter-organelle communication is still lacking, but important themes are beginning to emerge, primarily in budding yeast. These routes are reviewed here in the context of sub-system proteostasis and complex adaptive systems theory.
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1
Base de dados:
MEDLINE
Assunto principal:
Saccharomyces cerevisiae
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Organelas
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article