Macrophage heterogeneity and energy metabolism.
Exp Cell Res
; 360(1): 35-40, 2017 11 01.
Article
em En
| MEDLINE
| ID: mdl-28341447
ABSTRACT
Macrophages are versatile and multifunctional cell types present in most vertebrate tissues. They are the first line of defense against pathogens through phagocytosis of microbial infections, particles and dead cells. Macrophages harbor additional functions besides immune protection by participating in essential homeostatic and tissue development functions. The immune response requires a concomitant and coordinated regulation of the energetic metabolism. In this review, we will discuss how macrophages influence metabolic tissues and in turn how metabolic pathways, particularly glucose and lipid metabolism, affect macrophage phenotypes.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Metabolismo Energético
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Homeostase
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Macrófagos
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article