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A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk.
Manning, Alisa; Highland, Heather M; Gasser, Jessica; Sim, Xueling; Tukiainen, Taru; Fontanillas, Pierre; Grarup, Niels; Rivas, Manuel A; Mahajan, Anubha; Locke, Adam E; Cingolani, Pablo; Pers, Tune H; Viñuela, Ana; Brown, Andrew A; Wu, Ying; Flannick, Jason; Fuchsberger, Christian; Gamazon, Eric R; Gaulton, Kyle J; Im, Hae Kyung; Teslovich, Tanya M; Blackwell, Thomas W; Bork-Jensen, Jette; Burtt, Noël P; Chen, Yuhui; Green, Todd; Hartl, Christopher; Kang, Hyun Min; Kumar, Ashish; Ladenvall, Claes; Ma, Clement; Moutsianas, Loukas; Pearson, Richard D; Perry, John R B; Rayner, N William; Robertson, Neil R; Scott, Laura J; van de Bunt, Martijn; Eriksson, Johan G; Jula, Antti; Koskinen, Seppo; Lehtimäki, Terho; Palotie, Aarno; Raitakari, Olli T; Jacobs, Suzanne B R; Wessel, Jennifer; Chu, Audrey Y; Scott, Robert A; Goodarzi, Mark O; Blancher, Christine.
Afiliação
  • Manning A; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA.
  • Highland HM; Center for Human Genetic Research, Department of Medicine, Massachusetts General Hospital, Boston, MA.
  • Gasser J; Department of Medicine, Harvard Medical School, Boston, MA.
  • Sim X; Human Genetics Center, The University of Texas MD Anderson Cancer Center and The University of Texas Health Science Center at Houston Graduate School of Biomedical Sciences, Houston, TX.
  • Tukiainen T; Department of Epidemiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC.
  • Fontanillas P; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA.
  • Grarup N; Department of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI.
  • Rivas MA; Saw Swee Hock School of Public Health, National University of Singapore, Singapore.
  • Mahajan A; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA.
  • Locke AE; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA.
  • Cingolani P; Department of Genetics, Harvard Medical School, Boston, MA.
  • Pers TH; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA.
  • Viñuela A; 23andMe, Mountain View, CA.
  • Brown AA; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Wu Y; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, U.K.
  • Flannick J; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, U.K.
  • Fuchsberger C; Department of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI.
  • Gamazon ER; School of Computer Science, McGill University, Montreal, Canada.
  • Gaulton KJ; McGill University and Génome Québec Innovation Centre, Montreal, Canada.
  • Im HK; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA.
  • Teslovich TM; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Blackwell TW; Divisions of Endocrinology and Genetics and Genomics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, MA.
  • Bork-Jensen J; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
  • Burtt NP; Department of Twin Research & Genetic Epidemiology, King's College London, London, U.K.
  • Chen Y; Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland.
  • Green T; Institute of Genetics and Genomics in Geneva, University of Geneva, Geneva, Switzerland.
  • Hartl C; Wellcome Trust Sanger Institute, Hinxton, U.K.
  • Kang HM; Norwegian Centre for Mental Disorders Research and KG Jebsen Center for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
  • Kumar A; Department of Genetics, The University of North Carolina at Chapel Hill, Chapel Hill, NC.
  • Ladenvall C; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA.
  • Ma C; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA.
  • Moutsianas L; Department of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI.
  • Pearson RD; Section of Genetic Medicine, Department of Medicine, The University of Chicago, Chicago, IL.
  • Perry JRB; Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
  • Rayner NW; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, U.K.
  • Robertson NR; Department of Pediatrics, University of California, San Diego, La Jolla, CA.
  • Scott LJ; Section of Genetic Medicine, Department of Medicine, The University of Chicago, Chicago, IL.
  • van de Bunt M; Department of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI.
  • Eriksson JG; Department of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI.
  • Jula A; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Koskinen S; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA.
  • Lehtimäki T; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, U.K.
  • Palotie A; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA.
  • Raitakari OT; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA.
  • Jacobs SBR; Department of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI.
  • Wessel J; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, U.K.
  • Chu AY; Chronic Disease Epidemiology Unit, Swiss Tropical and Public Health Institute, University of Basel, Basel, Switzerland.
  • Scott RA; Diabetes and Endocrinology Unit, Department of Clinical Sciences Malmö, Lund University Diabetes Centre, Malmö, Sweden.
  • Goodarzi MO; Department of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI.
  • Blancher C; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, U.K.
Diabetes ; 66(7): 2019-2032, 2017 07.
Article em En | MEDLINE | ID: mdl-28341696

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Resistência à Insulina / Jejum / População Branca / Diabetes Mellitus Tipo 2 / Proteínas Proto-Oncogênicas c-akt / Insulina Tipo de estudo: Etiology_studies / Observational_studies / Risk_factors_studies Limite: Humans País como assunto: Europa Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Resistência à Insulina / Jejum / População Branca / Diabetes Mellitus Tipo 2 / Proteínas Proto-Oncogênicas c-akt / Insulina Tipo de estudo: Etiology_studies / Observational_studies / Risk_factors_studies Limite: Humans País como assunto: Europa Idioma: En Ano de publicação: 2017 Tipo de documento: Article